Phosphorylation-induced conformational changes have been well documented with different receptor tyrosine kinases. However, the susceptible epitopes and the tyrosine residue(s) involved in particular structural alteration mostly remain to be determined. Using a conformation-specific anti-peptide antibody, we have not only identified one such domain in the C-terminal tail of the EGF receptor but also identified the phosphate acceptor sites that are involved in the conformational change.
Research Article|October 01 1999
Conformational Analysis of the Phosphorylated Epidermal Growth Factor Receptor
Biosci Rep (1999) 19 (5): 397-402.
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Anupam Bishayee, Laura Beguinot, Subal Bishayee; Conformational Analysis of the Phosphorylated Epidermal Growth Factor Receptor. Biosci Rep 1 October 1999; 19 (5): 397–402. doi: https://doi.org/10.1023/A:1020260105524
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