Genomic clones of the human GM2 activator protein have been isolated and analyzed. The 5′ region of the gene demonstrated promoter activity as ascertained by its ability to drive luciferase gene expression in transfected COS cells. This sequence contains GC rich region and several putative promoter elements were present, including Sp1, AP2, cAMP-responsive element, and B-cell-specific activating protein. Analysis of tissue distribution of the GM2 activator protein gene revealed tissue-specific variations in transcript levels. Placenta, bone marrow, mammary gland, bladder, lymph node, and spleen had the highest mRNA levels.
Promoter Characterization and Expression of the Gene Coding for the Human GM2 Activator Protein
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Cite Icon Cite
Tommaso Beccari, Chiara Balducci, M. Cristina Aisa, M. Agnese Della Fazia, Giuseppe Servillo, Aldo Orlacchio; Promoter Characterization and Expression of the Gene Coding for the Human GM2 Activator Protein. Biosci Rep 1 February 2001; 21 (1): 55–62. doi: https://doi.org/10.1023/A:1010434101610
Download citation file: