When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, signalled oncomodulin to be a member of the troponin C superfamily. The presence of Cys-18 and Phe-66 in oncomodulin, plus its isoelectric point of 3.9) suggest that this tumour protein is a 8-parva Jbumin, rather than a muscle α-parvalbumin.
A new member of the troponin C superfamily: Comparison of the primary structures of rat oncomodulin and rat parvalbumin
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J. P. Mac Manus, D. C. Watson, M. Yaguchi; A new member of the troponin C superfamily: Comparison of the primary structures of rat oncomodulin and rat parvalbumin. Biosci Rep 1 November 1983; 3 (11): 1071–1075. doi: https://doi.org/10.1007/BF01121034
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