Chronic myeloid leukaemia (CML) cells are often characterized by the presence of a small chromosome 22, in which most of the q arm has been translocated to chromosome 9. Using cell hybrids containing different parts of chromosome 22 I have mapped the c-sis oncogene, which is known to be situated on chromosome 22, to a region distal to the CML breakpoint (22q112) and proximal to 22q13. This demonstrates that c-sis is translocated to chromosome 9 in CML cells.
Mapping of the c-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia
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Malcolm H. Goyns; Mapping of the c-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia. Biosci Rep 1 December 1983; 3 (12): 1107–1111. doi: https://doi.org/10.1007/BF01120203
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