The recovery, after inhibition by u.v.-irradiation, of phytohaemagglutinin-stimulated DNA synthesis is impaired in lymphocytes from patients with multiple actinic keratoses (AK) compared to the recovery in lymphocytes from age-matched, control individuals. This shows that the reduced level (50%) of DNA repair activity in AK ceils is sufficiently different from that in normal cells to significantly affect cellular activity.
Inhibition and recovery of DNA synthesis in PHA-stimulated u.v.-irradiated lymphocytes from patients with actinic keratosis
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Cite Icon Cite
J. M. Abo-Darub, R. Mackie, J. D. Pitts; Inhibition and recovery of DNA synthesis in PHA-stimulated u.v.-irradiated lymphocytes from patients with actinic keratosis. Biosci Rep 1 March 1983; 3 (3): 293–297. doi: https://doi.org/10.1007/BF01122462
Download citation file: