The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of proteoglycans into the extraceHular matrix may be controlled.
Research Article| October 01 1984
Delayed aggregation of proteoglycans in adult human articular cartilage
Michael T. Bayliss;
George D. Ridgway;
Biosci Rep (1984) 4 (10): 827–833.
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Michael T. Bayliss, George D. Ridgway, S. Yousuf Ali; Delayed aggregation of proteoglycans in adult human articular cartilage. Biosci Rep 1 October 1984; 4 (10): 827–833. doi: https://doi.org/10.1007/BF01138164
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