We demonstrate how the progressive passage through an interface simulated by a linear increase in dielectric constant may mediate a reversible transconformation of Na+/X337A (lasalocid A) from a cyclic to an extended structure, During the passage through the interface, the complex adopts progressively a more extended conformation favorable to the Na+ complexation or decomplexation at the interface.
Sequence of ionophore conformational changes induced by a simulated membrane/water interface
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Robert Brasseur, Michel Deleers, Jean-Marie Ruysschaert; Sequence of ionophore conformational changes induced by a simulated membrane/water interface. Biosci Rep 1 August 1984; 4 (8): 651–658. doi: https://doi.org/10.1007/BF01121018
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