In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and doJichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 49 h yielded mean output values of 9.0 ± 1,4 and 20.7 ± 3,0 μg/rat/day of dolichot and dolichy] phosphate, respectively. Urinary output rates were 0.56 ± 0.12 and 0.50 ± 0.2g μg/rat/ day of dolichol and dolichyt phosphate, respectively. Thus, excretion is one fate of endogenously synthesized dolichoI compounds in the rat.

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