Haemolysis by Sendal virus, α-toxin, and activated complement is inhibited by high concentrations of divalent cations. In Daudi cells, sublytic amounts of these agents induce the following changes: collapse of surface membrane potential, uptake of Na+ and loss of K+ from cells, and leakage of phosphorylated metabo-tites from cells. The changes induced by Sendal virus and complement are sensitive to physiological concentrations of extracellular Ca2+. It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain pore-forming agents on susceptible cells.
Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+
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C. L. Bashford, G. M. Alder, K. Patel, C. A. Pasternak; Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+. Biosci Rep 1 September 1984; 4 (9): 797–805. doi: https://doi.org/10.1007/BF01128822
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