The authors of the following paper “Endoplasmic Reticulum Ca2+ Release Causes Rieske Iron-Sulfur Protein-mediated Mitochondrial ROS Generation in Pulmonary Artery Smooth Muscle Cells” (Bioscience Reports (2019) 39(12) https://doi.org/10.1042/BSR20192414) would like to retract their paper. They have provided the following justification for retraction:
The results in the published paper indicated that mitochondrial ROS generation was increased by hypoxia treatment (see Figure 4A). Inhibition of RyRs with tetracaine or genetic deletion of RyR2 attenuated hypoxia-induced ROS generation in mitochondria (see Figure 4A,B). However, the authors have been unable to repeat the results in subsequent experiments, and their latest data have shown that deprivation of RyR2 is not able to attenuate hypoxia-induced ROS generation in mitochondria.
Inhibition or genetic deletion of RyR2 blocks hypoxic ROS production in mitochondria of PASMCs
All authors agree to the retraction, and apologise for any misunderstanding caused by their results.