Co-aggregates of NQO1 with Alzheimer’s beta peptide have been found which may contribute to protein aggregation diseases such as Alzheimer’s disease. In this issue of Bioscience Reports (volume 42, issue 11), Panja et al. probe the in vitro nature of NQO1 - Alzheimer’s beta peptide interactions and show that FAD-deficient NQO1 isoforms bind and accelerate the amyloid aggregation of Alzheimer’s beta peptide. A FAD-deficient genetic variant NQO1*2 is found in human populations and is associated with the prevalence of Alzheimer’s disease.