The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper “miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis” DOI: 10.1042/BSR20191255, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. It has been noted that the Western blots appear to have minimal background details and share similarities with other Western blots present in papers by different authors. Additionally, the ethical approval statements in the Materials and Methods do not specify the location where the approval was granted. The authors were contacted regarding the concerns, however so far the Editorial Office has not received a response.
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October 2024
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The cover of this issue of Bioscience Reports features the binding conformation of two flavonoids, quercetin and fisetin, bound to serine/threonine protein kinase 4 (STK4/MST1), an upstream kinase responsible for the Hippo-YAP signaling pathway. Although quercetin and fisetin share structural similarities, their effects on the functional properties of hMSCs are different. Read more in, ‘Effect of the polyphenol flavonoids fisetin and quercetin on the adipogenic differentiation of human mesenchymal stromal cells’ from Lorthongpanich and colleagues.
Expression of Concern|
October 07 2024
Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis
Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2024 The Author(s).
2024
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Biosci Rep (2024) 44 (10): BSR-2019-1255_EOC.
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This is an Expression of Concern to:
miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis
Citation
Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. Biosci Rep 30 October 2024; 44 (10): BSR–2019–1255_EOC. doi: https://doi.org/10.1042/BSR-2019-1255_EOC
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