Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of ceils. The number of low-affinity binding sites was significantly higher in parietal cells than in non-parietal cells. The reverse was true for the high-affinity binding sites. However, the affinity of each class of binding sites was similar in the cytosolic fractions of both parietal and non-parietal ceils. It thus appears that low-affinity somatostatin binding sites are mainly located in the parietal ceils whereas the high-affinity sites occur principally in the non-parietal cells.
Somatostatin binding sites in cytosolic fractions of parietal and non-parietal cells from rabbit fundic mucosa
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Eduardo Arilla, M. Pilar Löpez-Ruiz, Luis Gonzalez-Guijarro, Juan C. Prieto; Somatostatin binding sites in cytosolic fractions of parietal and non-parietal cells from rabbit fundic mucosa. Biosci Rep 1 April 1985; 5 (4): 321–328. doi: https://doi.org/10.1007/BF01116904
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