The induction of myocardial infarction in rats by ligation of the left – anterior coronary artery was confirmed by measurement of increased plasma levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase. Using this model system it has been established that intravenous administration of 12SI-labelled hyaluronidase to rats resulted in a preferential uptake of the enzyme by damaged myocardium as compared to normal heart tissue.
Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium
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Julia S. Earnshaw, Kheng H. Peh, Kenneth S. Dodgson, Anthony H. Olavesen, Peter Gacesa; Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium. Biosci Rep 1 April 1985; 5 (4): 329–334. doi: https://doi.org/10.1007/BF01116905
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