Decreasing extracellular sodium concentration was found to produce a contractile response of rabbit ileal smooth muscle. As the concentration decreases, the amplitude of contraction increases, thus producing a dose-dependent curve. Harmaline, a competitor for sodium, was found to inhibit the sodium gradient-dependent contractions in a dose-dependent manner. The results are interpreted as harmaline inhibiting a Na–Ca exchange mechanism present in ileal smooth muscle.
Research Article| August 01 1985
The role of transmembrane sodium gradient in rabbit ileal smooth muscle: Utilization of harmaline
Biosci Rep (1985) 5 (8): 667–671.
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M. S. Suleiman; The role of transmembrane sodium gradient in rabbit ileal smooth muscle: Utilization of harmaline. Biosci Rep 1 August 1985; 5 (8): 667–671. doi: https://doi.org/10.1007/BF01116998
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