Gabaculin (3-amino 2,3-dihydrobenzoic acid) is shown to be a very potent inhibitor of chlorophyll formation in Hordeum vulgate. Exposure of leaf segments to 30/μM gabaculin results in an 80% inhibition of chlorophyll synthesis, and this is paralleled by a decrease in carotenoid. Dual-inhibitor studies with dioxoheptanoic acid, which is an inhibitor of δ-aminolaevulinic acid dehydratase, show that gabaculin inhibits an earlier step than dioxoheptanoic acid and affects δ-aminolaevulinic acid synthesis rather than its subsequent metabolism.
Inhibition of chlorophyll synthesis in Hordeum vulgare by 3-amino 2,3-dihydrobenzoic acid (gabaculin)
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Corinne M. Hill, Sharon A. Pearson, Arnold J. Smith, Lyndon J. Rogers; Inhibition of chlorophyll synthesis in Hordeum vulgare by 3-amino 2,3-dihydrobenzoic acid (gabaculin). Biosci Rep 1 September 1985; 5 (9): 775–781. doi: https://doi.org/10.1007/BF01119876
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