A crude extract of human placenta has been demonstrated to stimulate growth, motility and the production of the proteases plasminogen activator and collagenase in cultured bovine capillary endothelial cells. These data are in keeping with the presence of an angiogenic factor(s) in human placenta.
Human placental tissue stimulates bovine capillary endothelial cell growth, migration and protease production
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M. Presta, P. Mignatti, D. E. Mullins, D. A. Moscatelli; Human placental tissue stimulates bovine capillary endothelial cell growth, migration and protease production. Biosci Rep 1 September 1985; 5 (9): 783–790. doi: https://doi.org/10.1007/BF01119877
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