A C3H/10T1/2 cell line containing an inducible metallothionein-ras hybrid oncogene was conditionally and reversibly transformed upon exposure to zinc ions. Interestingly, although the cell line was fully malignant when expressing only low levels of ras, complete morphological transformation required much higher levels.
Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene
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William S. Trimble, Gabrielle L. Boulianne, Nobumichi Hozumi; Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene. Biosci Rep 1 July 1987; 7 (7): 579–585. doi: https://doi.org/10.1007/BF01119775
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