Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.
Rapid Communication| July 01 1987
Mitochondrial pyruvate carrier—A possible link between gluconeogenesis and ketogenesis in the liver
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Ladislav Kümmel; Mitochondrial pyruvate carrier—A possible link between gluconeogenesis and ketogenesis in the liver. Biosci Rep 1 July 1987; 7 (7): 593–597. doi: https://doi.org/10.1007/BF01119777
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