Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in association with the shift of Thy-1 from the cell surface to the cytoplasm, suggesting biological significance of Thy-1 redistribution in muscle differentiation from single cells to multinucleated cells.
Changes of subcellular localization of Thy-1 antigen during thymic myoid cell differentiation
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Aiko Kikuchi, Isao Kamo, Kazumi Fujisawa, Ikuya Nonaka; Changes of subcellular localization of Thy-1 antigen during thymic myoid cell differentiation. Biosci Rep 1 October 1989; 9 (5): 605–613. doi: https://doi.org/10.1007/BF01119804
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