Glioma is the most common malignant tumor in the human central nervous system. Although heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) was previously presumed to be a tumor-promoting gene, the relationship between hnRNPA2/B1 and glioma is unclear. Targeting hnRNPA2/B1 interference in glioma cells can significantly inhibit proliferation and increase apoptosis of human glioma cells in vitro. In a tumor xenograft model, knockdown of hnRNPA2/B1 suppressed tumor growth in glioma cells in vivo. In terms of a mechanism, the knockdown of hnRNPA2/B1 led to inactivation of the AKT and STAT3 signaling pathways, which ultimately reduced the expression of B-cell lymphoma-2 (Bcl-2), CyclinD1 and proliferating cell nuclear antigen (PCNA). Collectively, these data suggest that the inhibition of hnRNPA2/B1 can reduce the growth of gliomas through STAT3 and AKT signaling pathways, and this inhibition is expected to be a therapeutic target for gliomas.
Research Article| May 28 2020
Effect of hnRNPA2/B1 on the Proliferation and Apoptosis of Glioma U251 Cells via the regulation of AKT and STAT3 pathways
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Decheng yin, Chengxiang Kong, Muhu Chen; Effect of hnRNPA2/B1 on the Proliferation and Apoptosis of Glioma U251 Cells via the regulation of AKT and STAT3 pathways. Biosci Rep BSR20190318. doi: https://doi.org/10.1042/BSR20190318
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