Background: The study was aimed to investigate the protective effect of Asarumsieboldii Miq. essential oil (AEO) on ovalbumin induced allergic rhinitis in rat. &#160;Methods and Results: Sixty Sprague Dawley male rats were randomly divided into 6 groups (n = 10): control, model, cetirizine (Cet, 4.65 g/kg), and AEO (0.5, 1.5, 3 g/kg) groups. All animals except the control group were received repeated intranasal instill 20 μL of 20% ovalbumin in Al(OH)3 saline solvent for 15 days. The control group were intranasal instillation of 5 mg/mL Al(OH)3 instead with the same procedure. In the 15 days, Cet and AEO were treated orally administration for 28 days. At the end of the drug administration, 20 μL of 5% ovalbumin was given to animals to stimulate allergic reaction, then detection the rat behavioral, assessment the patho-morphological changes in nasal mucosa, and determine the serum biomarkers. The result showed that AEO could significantly reduce the amount of nasal secretions, sneezing and the degree of nasal scratching of allergic rhinitis rat with EC50 = 1.5 and 2.8 g/kg, respectively. The degree of nasal mucosal inflammation in AEO group was improved, the levels of IgE, histamine, IL-4, IL-5, IL-17 were decreased and the level of IFN-γ was increased obviously with EC50 = 2 g/kg.</p> Conclusion: The study suggested that the possible mechanism might be related with the inhibition of histamine release and regulate the cytokine levels, which plays an important role in the treatment of allergic rhinitis.

This content is only available as a PDF.
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.