Recently, Rho GTPases substrates include Rac (Rac1 and Rac2) and Cdc42 have been reported to exert multiple cellular functions in osteoclasts, the most prominent of which includes regulating the dynamic actin cytoskeleton rearrangements. In addition, natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Although currently there has no report about the natural product, which could play a therapeutic role on bone loss diseases (osteoporosis and osteolysis) that through the regulation of Rac1/2 and Cdc42 during osteoclasts cytoskeletal structuring, there have several excellent studies for exploring the therapeutic potentials of various natural products for their role in inhibit cancer cells migration and function via regulating the Rac1/2 and Cdc42. Herein in this review, we try to focus on recent advances studies for extensively understanding the role of Rho GTPases substrates Rac1, Rac2 and Cdc42 in osteoclastogenesis, as well as therapeutic potentials of natural medicinal products for their properties on the regulation of Rac1, and/or Rac2 and Cdc42, which in order to inspire drug discovery in regulating osteoclastogenesis.

This content is only available as a PDF.
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.