Studies in mammals have shown that adiponectin is secreted mainly by adipocytes, and it plays a crucial role in glucose and lipid metabolism in muscles. Clarifying the crosstalk role of adiponectin between adipose tissue and skeletal muscle tissue is very important for internal homeostasis. The glucose and lipid metabolism of chicken is different from that of mammals, and the role of adiponectin in chickens is unclear. Therefore, it is of great significance to study the effect and mechanism of adiponectin on lipid metabolism in chickens. In this study, the regulating effect of adiponectin on lipid metabolism in chicken myoblasts was explored by adding a certain concentration of exogenous recombinant adiponectin. Results showed that adiponectin reduced intracellular lipid content, increasing the mRNA expression of adiponectin receptor and cellular uptake of glucose and fatty acids. In addition, adiponectin activated the 5′ adenosine monophosphate activated protein kinase (AMPK) signaling pathway. The above results suggested that adiponectin reduced intracellular lipid content, mainly by binding to adiponectin receptor, activating AMPK pathway, increasing cellular uptake of glucose and fatty acids, and promoting lipid oxidation.
Skip Nav Destination
Article navigation
Research Article|
May 23 2022
Adiponectin Reduces Lipid Content in Chicken Myoblasts by Activating AMPK Signaling Pathway
Qingmei Hu;
Qingmei Hu
Shandong Agricultural University, Tai'an, China
Search for other works by this author on:
Dan Wang;
Dan Wang
Shandong Agricultural University, Tai'an, China
Search for other works by this author on:
Hai Lin;
Hai Lin
Shandong Agricultural University, Taian, China
Search for other works by this author on:
Haifang Li;
Haifang Li
Shandong Agricultural University, Tai'an, China
Search for other works by this author on:
Jingpeng Zhao;
Jingpeng Zhao
Shandong Agricultural University, Tai'an, China
Search for other works by this author on:
Hong Chao Jiao;
Hong Chao Jiao
Shandong Agricultural University, Taian, China
Search for other works by this author on:
Xiaojuan Wang
Shandong Agricultural University, Tai'an, China
* Corresponding Author; email: [email protected]
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
November 05 2021
Revision Received:
May 03 2022
Accepted:
May 20 2022
Online ISSN: 1573-4935
Print ISSN: 0144-8463
Copyright 2022 The Author(s)
2022
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.
Biosci Rep (2022) BSR20212549.
Article history
Received:
November 05 2021
Revision Received:
May 03 2022
Accepted:
May 20 2022
Citation
Qingmei Hu, Dan Wang, Hai Lin, Haifang Li, Jingpeng Zhao, Hong Chao Jiao, Xiaojuan Wang; Adiponectin Reduces Lipid Content in Chicken Myoblasts by Activating AMPK Signaling Pathway. Biosci Rep 2022; BSR20212549. doi: https://doi.org/10.1042/BSR20212549
Download citation file:
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |