Porcine deltacoronavirus (PDCoV) is an newly emerged enteropathogenic coronavirus, mainly causing diarrhea in suckling piglets, and also has the potential for cross-species transmission. However, there are no effective vaccines or specific therapeutic agents for PDCoV. This study investigates the antiviral properties of baicalein against PDCoV infection in swine testicle cells (ST). It reveals that baicalein exerts a dose-dependent inhibitory effect on PDCoV replication, primarily targeting the replication stage of the viral infection by impeding viral RNA and protein synthesis. Furthermore, treatment with baicalein leads to reduced phosphorylation of PI3K, AKT, and NF-κB p65 proteins, along with decreased mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α). These results signify that PDCoV replication is inhibited through the inhibition of the PI3K-Akt-NF-κB protein signaling pathway, thereby suppressing the inflammatory response. In conclusion, it underscores the potential of baicalein as a therapeutic candidate for treating PDCoV infection.
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Research Article|
May 07 2024
Antiviral effect of baicalein on Porcine Deltacoronavirus infection by regulating the inflammatory responses through PI3K-Akt-NF-κB signaling pathway in cultured cells
Hejuan Liu;
Hejuan Liu
Henan University of Chinese Medicine, zhengzhou, China
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Zhanyong Wei;
Zhanyong Wei
Henan Agricultural University, Zhengzhou, Henan, P. R. China, Zhengzhou, China
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Chenxi Shi;
Chenxi Shi
Henan Agricultural University, zhen zhou, China
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Lu Xia;
Lu Xia
Henan Agricultural University, zhen zhou, China
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Yunfei Zhang;
Yunfei Zhang
Henan Agricultural University, zhen zhou, China
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Jing Wang;
Jing Wang
Henan University of Chinese Medicine, zhengzhou, China
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Meile Wang;
Meile Wang
Henan University of Chinese Medicine, zhengzhou, China
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Sugai Yin;
Henan University of Chinese Medicine, zhengzhou, China
* Corresponding Author; email: [email protected]
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Xianqing Ren
Xianqing Ren
Henan University of Chinese Medicine, zhengzhou, China
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Publisher: Portland Press Ltd
Received:
November 07 2023
Revision Received:
February 27 2024
Accepted:
March 05 2024
Online ISSN: 1573-4935
Print ISSN: 0144-8463
Funding
Funding Group:
- Award Group:
- Funder(s):
- Award Id(s): 202102310504
- Principal Award Recipient(s): SugaiYin
- Funder(s):
- Award Group:
- Funder(s):
- Award Id(s): 32130106
- Principal Award Recipient(s): ZhanyongWei
- Funder(s):
- Award Group:
- Funder(s):
- Award Id(s): 2022ZYLCYJ01-2
- Principal Award Recipient(s): XianqingRen
- Funder(s):
Copyright 2024 The Author(s)
2024
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.
Biosci Rep (2024) BSR20231930.
Article history
Received:
November 07 2023
Revision Received:
February 27 2024
Accepted:
March 05 2024
Citation
Hejuan Liu, Zhanyong Wei, Chenxi Shi, Lu Xia, Yunfei Zhang, Jing Wang, Meile Wang, Sugai Yin, Xianqing Ren; Antiviral effect of baicalein on Porcine Deltacoronavirus infection by regulating the inflammatory responses through PI3K-Akt-NF-κB signaling pathway in cultured cells. Biosci Rep 2024; BSR20231930. doi: https://doi.org/10.1042/BSR20231930
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