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January 2020
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Cover Image
Cover Image
Active site view of the plant molybdenum insertase Cnx1E: bound AMP and molybdate ions are shown in stick representation, the active site magnesium ion and its water hydration shell are shown as spheres, the active site loop is shown in red and includes amino acid residue Asp274 (stick representation) which is essential for Cnx1E hydrolysis activity; The Cnx1E reaction product is the molybdenum cofactor (Moco) which is illustrated beneath the Cnx1E structure. Cnx1E Asp274 mutants accumulate the Moco precursor adenylated molybdopterin, thus providing the molecular framework required for subsequent research work devoted to elucidate the mechanism behind molybdate insertion into the MPT dithiolene motif which is intrinsically tied to Moco formation. Read more about Cnx1E catalysed MPT-AMP hydrolysis in the article by Hercher et al.
ISSN 0144-8463
EISSN 1573-4935
In this Issue
Review Articles
Research Articles
Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway
Yun Huang; Chen Liu; Wu-Cha Zeng; Guo-Yan Xu; Jian-Min Wu; Zhi-Wen Li; Xuan-Yu Huang; Rong-Jin Lin; Xi Shi
Biosci Rep (2020) 40 (1): BSR20192727.
Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model
Biosci Rep (2020) 40 (1): BSR20191672.
miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer
Biosci Rep (2020) 40 (1): BSR20193158.
Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease
Wei Hou; Michael G. Janech; Philip M. Sobolesky; Alison M. Bland; Salma Samsuddin; William Alazawi; Wing-Kin Syn
Biosci Rep (2020) 40 (1): BSR20190395.
LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways
Biosci Rep (2020) 40 (1): BSR20191265.
Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis
Biosci Rep (2020) 40 (1): BSR20192061.
Live-cell monitoring of protein localization to membrane rafts using protein-fragment complementation
Biosci Rep (2020) 40 (1): BSR20191290.
PtdIns4P-mediated electrostatic forces influence S-acylation of peripheral proteins at the Golgi complex
Biosci Rep (2020) 40 (1): BSR20192911.
The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma
Biosci Rep (2020) 40 (1): BSR20191251.
Association between FAS gene −670 A/G and −1377 G/A polymorphisms and the risk of autoimmune diseases: a meta-analysis
Biosci Rep (2020) 40 (1): BSR20191197.
Serum albumin level for prediction of all-cause mortality in acute coronary syndrome patients: a meta-analysis
Biosci Rep (2020) 40 (1): BSR20190881.
Decompressive hemicraniectomy versus medical treatment of malignant middle cerebral artery infarction: a systematic review and meta-analysis
Biosci Rep (2020) 40 (1): BSR20191448.
Obesity associated with a novel mitochondrial tRNACys 5802A>G mutation in a Chinese family
Jinling Wang; Ningning Zhao; Xiaoting Mao; Feilong Meng; Ke Huang; Guanping Dong; Yanchun Ji; JunFen Fu
Biosci Rep (2020) 40 (1): BSR20192153.
IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility
Biosci Rep (2020) 40 (1): BSR20191449.
Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis
Yuan-Zhi Chen; Li-Chang Sun; Yao-Hong Wen; Zhong-Wei Li; Shu-Jin Fan; Hong-Kun Tan; Min Qiu; Zhi-Yong Pan; Qin Li; Yan-Zhen Zhao; Zhen-Xing Li; Xu-Guang Guo
Biosci Rep (2020) 40 (1): BSR20191312.
Prediabetes predicts adverse cardiovascular outcomes after percutaneous coronary intervention: a meta-analysis
Biosci Rep (2020) 40 (1): BSR20193130.
microRNA-217 suppressed epithelial-to-mesenchymal transition through targeting PTPN14 in gastric cancer
Biosci Rep (2020) 40 (1): BSR20193176.
Development of a topical tissue cross-linking solution using sodium hydroxymethylglycinate (SMG): viscosity effect
Biosci Rep (2020) 40 (1): BSR20191941.
Insights into the Cnx1E catalyzed MPT-AMP hydrolysis
Thomas W. Hercher; Joern Krausze; Sven Hoffmeister; Dagmar Zwerschke; Thomas Lindel; Wulf Blankenfeldt; Ralf R. Mendel; Tobias Kruse
Biosci Rep (2020) 40 (1): BSR20191806.
Up-regulated microRNA-33b inhibits epithelial–mesenchymal transition in gallbladder cancer through down-regulating CROCC
Biosci Rep (2020) 40 (1): BSR20190108.
MicroRNA-221 is a potential biomarker of myocardial hypertrophy and fibrosis in hypertrophic obstructive cardiomyopathy
Biosci Rep (2020) 40 (1): BSR20191234.
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity
Katherine A. Staines; Mark Hopkinson; Scott Dillon; Louise A. Stephen; Robert Fleming; Antonia Sophocleous; David J. Buttle; Andrew A. Pitsillides; Colin Farquharson
Biosci Rep (2020) 40 (1): BSR20190329.
Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction
Biosci Rep (2020) 40 (1): BSR20191017.
Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival
Biosci Rep (2020) 40 (1): BSR20192546.
Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis
Chang-Mei Weng; Qing Li; Kui-Jun Chen; Cheng-Xiong Xu; Meng-Sheng Deng; Tao Li; Dong-Dong Zhang; Zhao-Xia Duan; Zhi-Qiang Chen; Guan-Hua Li; Jing Chen; Jian-Min Wang
Biosci Rep (2020) 40 (1): BSR20190756.
Exopolysaccharides isolated from Rhizopus nigricans induced colon cancer cell apoptosis in vitro and in vivo via activating the AMPK pathway
Biosci Rep (2020) 40 (1): BSR20192774.
17β-estradiol binding to ERα promotes the progression of prolactinoma through estrogen-response element-induced CaBP-9k up-regulation
Biosci Rep (2020) 40 (1): BSR20191330.
STAT3-induced up-regulation of lncRNA NEAT1 as a ceRNA facilitates abdominal aortic aneurysm formation by elevating TULP3
Biosci Rep (2020) 40 (1): BSR20193299.
Survival and prognostic factors of patients with esophageal fistula in advanced esophageal squamous cell carcinoma
Xin Guan; Chao Liu; Tianshuo Zhou; Zhigang Ma; Chunhui Zhang; Bojun Wang; Yang Yao; Xiaona Fan; Zhiwei Li; Yanqiao Zhang
Biosci Rep (2020) 40 (1): BSR20193379.
The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis
Biosci Rep (2020) 40 (1): BSR20192666.
2-Methylquinazoline derivative 23BB as a highly selective histone deacetylase 6 inhibitor alleviated cisplatin-induced acute kidney injury
Yan Hao; Fan Guo; Zhuo Huang; Yuying Feng; Zijing Xia; Jing Liu; Lingzhi Li; Rongshuang Huang; Lin Lin; Liang Ma; Ping Fu
Biosci Rep (2020) 40 (1): BSR20191538.
Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer
Biosci Rep (2020) 40 (1): BSR20190303.
RCAN1.4 mediates high glucose-induced matrix production by stimulating mitochondrial fission in mesangial cells
Biosci Rep (2020) 40 (1): BSR20192759.
The protective role of MiR-206 in regulating cardiomyocytes apoptosis induced by ischemic injury by targeting PTP1B
Biosci Rep (2020) 40 (1): BSR20191000.
Eupatilin alleviates airway remodeling via regulating phenotype plasticity of airway smooth muscle cells
Biosci Rep (2020) 40 (1): BSR20191445.
ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption
Biosci Rep (2020) 40 (1): BSR20192465.
The association between dietary protein intake and esophageal cancer risk: a meta-analysis
Biosci Rep (2020) 40 (1): BSR20193692.
Efficacy and safety of Chinese patent medicine (Jinlong capsule) in the treatment of advanced hepatocellular carcinoma: a meta-analysis
Biosci Rep (2020) 40 (1): BSR20194019.
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer
Biosci Rep (2020) 40 (1): BSR20191488.
Foam cells promote atherosclerosis progression by releasing CXCL12
Lingxing Li; Zhenlan Du; Bing Rong; Dapeng Zhao; Aiping Wang; Yuzhen Xu; Huanyi Zhang; Xue Bai; Jingquan Zhong
Biosci Rep (2020) 40 (1): BSR20193267.
FOXM1/LINC00152 feedback loop regulates proliferation and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via Wnt/β-catenin signaling pathway
Biosci Rep (2020) 40 (1): BSR20191900.
Hydrolysis of three different head groups phospholipids by chicken group V phospholipase A2 using the monomolecular film technique
Biosci Rep (2020) 40 (1): BSR20192053.
Identification of 13 novel USH2A mutations in Chinese retinitis pigmentosa and Usher syndrome patients by targeted next-generation sequencing
Ling-hui Qu; Xin Jin; Yan-ling Long; Jia-yun Ren; Chuang-huang Weng; Hai-wei Xu; Yong Liu; Xiao-hong Meng; Shi-ying Li; Zheng-qin Yin
Biosci Rep (2020) 40 (1): BSR20193536.
MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline
Weifeng Yao; Xiaoyu Lin; Xue Han; Lanfen Zeng; Anshun Guo; Yu Guan; Ziqing Hei; Jianpei Liu; Pinjie Huang
Biosci Rep (2020) 40 (1): BSR20191043.
Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes in head and neck squamous cell carcinoma
Biosci Rep (2020) 40 (1): BSR20193349.
NORAD accelerates chemo-resistance of non-small-cell lung cancer via targeting at miR-129-1-3p/SOX4 axis
Biosci Rep (2020) 40 (1): BSR20193489.
Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1
Biosci Rep (2020) 40 (1): BSR20193309.
A susceptibility biomarker identification strategy based on significantly differentially expressed ceRNA triplets for ischemic cardiomyopathy
Yuqing Zou; Yahui Wang; Zherou Rong; Benliang Wei; Yang Liu; Zhaona Song; Wenshuai Li; Erqiang Hu; Gui Deng; Yuehan He; Junjie Lv; Lina Chen; Wan Li
Biosci Rep (2020) 40 (1): BSR20191731.
Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway
Biosci Rep (2020) 40 (1): BSR20193482.
Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate
Biosci Rep (2020) 40 (1): BSR20192345.
Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model
Biosci Rep (2020) 40 (1): BSR20193667.
Immobilized DNA aptamers used as potent attractors for vascular endothelial cell: in vitro study of female rat
Biosci Rep (2020) 40 (1): BSR20182444.
HbA1c may contribute to the development of non-alcoholic fatty liver disease even at normal-range levels
Biosci Rep (2020) 40 (1): BSR20193996.
Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA–miRNA–mRNA networks and Cox regression models
Biosci Rep (2020) 40 (1): BSR20191554.
Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates
Biosci Rep (2020) 40 (1): BSR20192152.
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish
Biosci Rep (2020) 40 (1): BSR20194191.
The prognostic value of lncRNA SNHG4 and its potential mechanism in liver cancer
Biosci Rep (2020) 40 (1): BSR20190729.
The role of DOT1L in the proliferation and prognosis of gastric cancer
Biosci Rep (2020) 40 (1): BSR20193515.
