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January 2021
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Cover Image
Cover Image
The cover of this issue of Bioscience Reports (volume 41, issue 1) features the crystal structure of aldehyde dehydrogenase (AldA) from a research article by Zhang et al. on indole-3-acetaldehyde dehydrogenase. The plant pathogenic microbe Pseudomonas syringae uses AldA for the synthesis of indole acetic acid (IAA), a major plant hormone. The x-ray crystal structure of AldA in complex with IAA helps understand how these enzyme recognizes substrate and performs its reaction chemistry.
ISSN 0144-8463
EISSN 1573-4935
In this Issue
Review Articles
Research Articles
miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway
Biosci Rep (2021) 41 (1): BSR20201539.
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer
Biosci Rep (2021) 41 (1): BSR20203282.
Identification of immune-based prostate cancer subtypes using mRNA expression
Biosci Rep (2021) 41 (1): BSR20201533.
Down-regulation of miR-let-7e attenuates LPS-induced acute lung injury in mice via inhibiting pulmonary inflammation by targeting SCOS1/NF-κB pathway
Biosci Rep (2021) 41 (1): BSR20201089.
Lack of association between miR-146a rs2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis
Biosci Rep (2021) 41 (1): BSR20191729.
GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson’s disease
Ting Dong; Ming-cai Wu; Lu-lu Tang; Hai-lin Jiang; Ping Zhou; Chun-jun Kuang; Li-wei Tian; Wen-ming Yang
Biosci Rep (2021) 41 (1): BSR20202717.
Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells
Jonathan J. Sheard; Andrew D. Southam; Hannah L. MacKay; Max A. Ellington; Martyn D. Snow; Farhat L. Khanim; Christopher M. Bunce; William E. Johnson
Biosci Rep (2021) 41 (1): BSR20202505.
An epithelial–mesenchymal transition-related long noncoding RNA signature correlates with the prognosis and progression in patients with bladder cancer
Biosci Rep (2021) 41 (1): BSR20203944.
Small angle X-ray scattering analysis of ligand-bound forms of tetrameric apolipoprotein-D
Biosci Rep (2021) 41 (1): BSR20201423.
Effects of long-term antibiotic treatment on mice urinary aromatic amino acid profiles
Biosci Rep (2021) 41 (1): BSR20203498.
Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9
Biosci Rep (2021) 41 (1): BSR20203595.
NPHS2 gene polymorphism aggravates renal damage caused by focal segmental glomerulosclerosis with COL4A3 mutation
Biosci Rep (2021) 41 (1): BSR20203248.
Prognostic and immunological role of Fam20C in pan-cancer
Xinpeng Liu; Yuanbo Zhan; Wenxia Xu; Xiaoyao Liu; Yawei Geng; Lixue Liu; Junlong Da; Jianqun Wang; Xinjian Zhang; Han jin; Zhongshuang Liu; Shouli Guo; Bin Zhang; Ying Li
Biosci Rep (2021) 41 (1): BSR20201920.
FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity
Chang-Kyu Oh; Yeji Ko; Jeong Jun Park; Hye Jin Heo; Junho Kang; Eun Jung Kwon; Ji Wan Kang; Yoonsung Lee; Kyungjae Myung; Jin Mo Kang; Dai Sik Ko; Yun Hak Kim
Biosci Rep (2021) 41 (1): BSR20203204.
Bioinformatic analysis of key pathways and genes involved in pediatric atopic dermatitis
Biosci Rep (2021) 41 (1): BSR20193517.
The N-terminus of Paenibacillus larvae C3larvinA modulates catalytic efficiency
Biosci Rep (2021) 41 (1): BSR20203727.
Contrasting association of Leptin receptor polymorphisms and haplotypes with polycystic ovary syndrome in Bahraini and Tunisian women: a case–control study
Meriem Dallel; Zeineb Douma; Ramzi R. Finan; Feten Hachani; Dhafer B. Letaifa; Touhami Mahjoub; Wassim Y. Almawi
Biosci Rep (2021) 41 (1): BSR20202726.
Reference values and the effect of clinical parameters on thyroid hormone levels during early pregnancy
Biosci Rep (2021) 41 (1): BSR20202296.
Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis
Mohammed H. Hassan; Sawsan Abuhamdah; Mohamed Abdel-Bary; Mohammed Wahman; Tarek Hamdy Abd-Elhamid; Morris Beshay; Karam Mosallam; Bakheet E.M. Elsadek
Biosci Rep (2021) 41 (1): BSR20203097.
Developing a risk scoring system based on immune-related lncRNAs for patients with gastric cancer
Biosci Rep (2021) 41 (1): BSR20202203.
Association of α-fetoprotein levels with liver stiffness measurement in outpatients with chronic hepatitis B
Biosci Rep (2021) 41 (1): BSR20203048.
Identification of ribosomal protein family in triple-negative breast cancer by bioinformatics analysis
Biosci Rep (2021) 41 (1): BSR20200869.
The correlation of microRNA-499 rs3746444 T>C locus with the susceptibility of gastric cancer: from a case–control study to a meta-analysis
Biosci Rep (2021) 41 (1): BSR20203461.
Human-derived NLS enhance the gene transfer efficiency of chitosan
Diogo B. Bitoque; Joana Morais; Ana V. Oliveira; Raquel L. Sequeira; Sofia M. Calado; Tiago M. Fortunato; Sónia Simão; Ana M. Rosa da Costa; Gabriela A. Silva
Biosci Rep (2021) 41 (1): BSR20201026.
Uronic acid metabolic process–related gene expression–based signature predicts overall survival of glioma
Yuemei Feng; Guanzhang Li; Zhongfang Shi; Xu Yan; Renpeng Li; You Zhai; Yuanhao Chang; Di Wang; Ulf Dietrich Kahlert; Wei Zhang; Fang Yuan
Biosci Rep (2021) 41 (1): BSR20203051.
The diagnostic and prognostic values of microRNA-196a in cancer
Biosci Rep (2021) 41 (1): BSR20203559.
Development of a prognostic model based on an immunogenomic landscape analysis of medulloblastoma
Biosci Rep (2021) 41 (1): BSR20202907.
Elevated CDK5R1 predicts worse prognosis in hepatocellular carcinoma based on TCGA data
Biosci Rep (2021) 41 (1): BSR20203594.
microRNA-27b inhibits cell proliferation and invasion in bladder cancer by targeting engrailed-2
Biosci Rep (2021) 41 (1): BSR20201000.
Identification of an immune-related six-long noncoding RNA signature as a novel prognosis biomarker for adenocarcinoma of lung
Biosci Rep (2021) 41 (1): BSR20202444.
CXCL10 is a potential biomarker and associated with immune infiltration in human papillary thyroid cancer
Biosci Rep (2021) 41 (1): BSR20203459.
Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential
Sahida Akter; Israt Jahan; Mst. Riniara Khatun; Mohammad Forhad Khan; Laiba Arshad; Md. Jakaria; Md. Areeful Haque
Biosci Rep (2021) 41 (1): BSR20203022.
Comprehensive analysis reveals a prognostic and therapeutic biomarker CD3D in the breast carcinoma microenvironment
Zhipeng Zhu; Weipeng Ye; Xiaofang Wu; Sihao Lin; Jiuhua Xu; Lulu Li; Jiayi Li; Haibin Wang; Zhengjie Huang
Biosci Rep (2021) 41 (1): BSR20202898.
MicroRNA-409-3p promotes osteoblastic differentiation via activation of Wnt/β-catenin signaling pathway by targeting SCAI
Biosci Rep (2021) 41 (1): BSR20201902.
Biochemical characterization of an E. coli cell division factor FtsE shows ATPase cycles similar to the NBDs of ABC-transporters
Biosci Rep (2021) 41 (1): BSR20203034.
The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality
Eliza Wyszko; Mariusz Popenda; Dorota Gudanis; Joanna Sarzyńska; Agnieszka Belter; Patrick Perrigue; Paweł Skowronek; Katarzyna Rolle; Jan Barciszewski
Biosci Rep (2021) 41 (1): BSR20203424.
Identifying breast cancer subtypes associated modules and biomarkers by integrated bioinformatics analysis
Biosci Rep (2021) 41 (1): BSR20203200.
Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer
Biosci Rep (2021) 41 (1): BSR20202564.
Toxicity profiling of the ethanolic extract of Citrullus lanatus seed in rats: behavioral, biochemical and histopathological aspects
Biosci Rep (2021) 41 (1): BSR20202345.
A paradox: Fe2+-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1α
Biosci Rep (2021) 41 (1): BSR20203456.
A panel of two miRNAs correlated to systolic blood pressure is a good diagnostic indicator for stroke
Biosci Rep (2021) 41 (1): BSR20203458.
KCNQ1OT1 regulates the retinoblastoma cell proliferation, migration and SIRT1/JNK signaling pathway by targeting miR-124/SP1 axis
Biosci Rep (2021) 41 (1): BSR20201626.
Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response
Shams Tabrez; Fazlur Rahman; Rahat Ali; Abdulaziz S. Alouffi; Sajjadul Kadir Akand; Bader Mohammed Alshehri; Fahdah Ayed Alshammari; Aftab Alam; Mohammed A. Alaidarous; Saeed Banawas; Abdul Aziz Bin Dukhyil; Abdur Rub
Biosci Rep (2021) 41 (1): BSR20203857.
Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6
Biosci Rep (2021) 41 (1): BSR20202583.
Sex-related differences in human plasma NAD+/NADH levels depend on age
Biosci Rep (2021) 41 (1): BSR20200340.
Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis
Biosci Rep (2021) 41 (1): BSR20203130.
Integrative analysis of miRNA–mRNA network in high altitude retinopathy by bioinformatics analysis
Biosci Rep (2021) 41 (1): BSR20200776.
Stool DNA test targeting methylated syndecan-2 (SDC2) as a noninvasive screening method for colorectal cancer
Wei-Chih Su; Wei-Yu Kao; Tsung-Kun Chang; Hsiang-Lin Tsai; Ching-Wen Huang; Yen-Cheng Chen; Ching-Chun Li; Yi-Chien Hsieh; Hsing-Jung Yeh; Chun-Chao Chang; Jaw-Yuan Wang
Biosci Rep (2021) 41 (1): BSR20201930.
Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis
Biosci Rep (2021) 41 (1): BSR20203995.
Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma
Biosci Rep (2021) 41 (1): BSR20203231.
Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries
Biosci Rep (2021) 41 (1): BSR20202022.
Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics
Peili Zhang; Zhanquan Li; Faman Yang; Linhua Ji; Yingzhong Yang; Chuanchuan Liu; Huihui Liu; Jie Ma; Jie Liu; Zhancui Dang; Shengyan Wang; Rili Ge; Sen Cui
Biosci Rep (2021) 41 (1): BSR20202219.
Sarcocystis camelicanis increases interleukin (IL)-6 expression in one-humped camels (Camelus dromedarius) from Riyadh and Al Qassim, Saudi Arabia
Biosci Rep (2021) 41 (1): BSR20203140.
Insight into molecular profile changes after skeletal muscle contusion using microarray and bioinformatics analyses
Na Li; Ru-feng Bai; Chun Li; Li-hong Dang; Qiu-xiang Du; Qian-qian Jin; Jie Cao; Ying-yuan Wang; Jun-hong Sun
Biosci Rep (2021) 41 (1): BSR20203699.
Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis
Jae Han Lee; So Hee Han; You Min Kim; Sung Hyun Kim; Eun Seon Yoo; Joong Seok Woo; Gi Hwan Jung; Soo Hyun Jung; Bum Seok Kim; Ji Youn Jung
Biosci Rep (2021) 41 (1): BSR20203834.
LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p
Biosci Rep (2021) 41 (1): BSR20202298.
Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer
Biosci Rep (2021) 41 (1): BSR20203115.
Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats
Biosci Rep (2021) 41 (1): BSR20203824.
Optimization of the isolation procedure and culturing conditions for hepatic stellate cells obtained from mouse
Thanh Minh Dang; Trinh Van Le; Huy Quang Do; Van Thuan Nguyen; Ai Xuan Le Holterman; Loan Tung Thi Dang; Nhan Chinh Lu Phan; Phuc Van Pham; Son Nghia Hoang; Long Thanh Le; Gabriele Grassi; Nhung Hai Truong
Biosci Rep (2021) 41 (1): BSR20202514.
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis
Biosci Rep (2021) 41 (1): BSR20203973.
Total saponins from Rubus parvifolius L. inhibits cell proliferation, migration and invasion of malignant melanoma in vitro and in vivo
Biosci Rep (2021) 41 (1): BSR20201178.
Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer
Biosci Rep (2021) 41 (1): BSR20203481.
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation
Biosci Rep (2021) 41 (1): BSR20200842.
Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3
Biosci Rep (2021) 41 (1): BSR20203495.
The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro
Biosci Rep (2021) 41 (1): BSR20203003.
Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19
Biosci Rep (2021) 41 (1): BSR20202074.
Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway
Biosci Rep (2021) 41 (1): BSR20203219.
Revealing mechanism of Caulis Sargentodoxae for the treatment of ulcerative colitis based on network pharmacology approach
Biosci Rep (2021) 41 (1): BSR20204005.
Effects of continuous positive airway pressure on plasma fibrinogen levels in obstructive sleep apnea patients: a systemic review and meta-analysis
Biosci Rep (2021) 41 (1): BSR20203856.
A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats
Venkatesh Gopalan; Jadegoud Yaligar; Navin Michael; Kavita Kaur; Rengaraj Anantharaj; Sanjay Kumar Verma; Suresh Anand Sadananthan; Giang Thi Thu Le; Jorming Goh; S. Sendhil Velan
Biosci Rep (2021) 41 (1): BSR20201707.
Baseline monocyte and its classical subtype may predict efficacy of PD-1/PD-L1 inhibitor in cancers
Biosci Rep (2021) 41 (1): BSR20202613.
Lamin B2 promotes the progression of triple negative breast cancer via mediating cell proliferation and apoptosis
Biosci Rep (2021) 41 (1): BSR20203874.
Computational analysis of Cyclin D1 gene SNPs and association with breast cancer
Ayesha Aftab; Ranjha Khan; Wasim Shah; Muhammad Azhar; Ahsanullah Unar; Hafiz Muhammad Jafar Hussain; Ahmed Waqas
Biosci Rep (2021) 41 (1): BSR20202269.
