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Keywords: AMPK
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Biosci Rep (2022) BSR20212549.
Published: 23 May 2022
... expression of adiponectin receptor and cellular uptake of glucose and fatty acids. In addition, adiponectin activated the 5′ adenosine monophosphate activated protein kinase (AMPK) signaling pathway. The above results suggested that adiponectin reduced intracellular lipid content, mainly by binding...
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Biosci Rep (2020) 40 (11): BSR20200661.
Published: 19 November 2020
... that Sop significantly mitigated TAC-induced heart dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis. Mechanistically, Sop treatment induced a remarkable activation of AMPK/mTORC1-autophagy cascade following sustained hypertrophic stimulation. Importantly, the protective effect of Sop was largely...
Includes: Supplementary data
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Biosci Rep (2019) 39 (12): BSR20192504.
Published: 13 December 2019
...Xiang-zi Zhang; Mo-han Zhang; Xue-sen Fang; Xiang-shu Cui; Zheng Jin To observe changes in AMP-activated protein kinase (AMPK) activity and phosphorylation changes in AMPK signaling pathway in gastric smooth muscle cells of rats with diabetic gastroparesis (DGP), investigate the effect of AMPK...
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Biosci Rep (2019) 39 (12): BSR20191860.
Published: 04 December 2019
... banding. Four weeks post-surgery, CRA-treated mice developed blunted cardiac hypertrophy, fibrosis, and dysfunction, and showed increased LC3 II and p-AMPK expression. In line with the in vivo studies, CRA also inhibited the hypertrophic response induced by PE stimulation accompanying with increased LC3...
Includes: Supplementary data
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Biosci Rep (2019) 39 (9): BSR20181994.
Published: 03 September 2019
... also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy...
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Biosci Rep (2019) 39 (5): BSR20182378.
Published: 14 May 2019
.... ( 2013 ) Endoplasmic reticulum dysfunction in neurological disease . Lancet Neurol. 12 , 105 – 118 10.1016/S1474-4422(12)70238-7 23237905 23. Santosh R. and Gabriele R. ( 2012 ) AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain . Exp. Neurobiol. 21...
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Biosci Rep (2019) 39 (2): BSR20181995.
Published: 15 February 2019
... is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injury...
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Biosci Rep (2019) 39 (1): BSR20181767.
Published: 03 January 2019
... processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ATP production...
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Biosci Rep (2018) 38 (4): BSR20170982.
Published: 18 July 2018
...Yanhui Li; Yan Wang; Man Zou; Cong Chen; Yili Chen; Ruicong Xue; Yugang Dong; Chen Liu AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, has been shown to exert a protective effect against cardiac hypertrophy and heart failure. Our previous reports have demonstrated that AMPK...
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Biosci Rep (2018) 38 (3): BSR20180242.
Published: 08 May 2018
...Audrey E. Brown; Beth Dibnah; Emily Fisher; Julia L. Newton; Mark Walker Skeletal muscle fatigue and post-exertional malaise are key symptoms of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (ME/CFS). We have previously shown that AMP-activated protein kinase (AMPK) activation and glucose...
Includes: Supplementary data
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Biosci Rep (2014) 34 (2): e00105.
Published: 15 April 2014
... (circulating tumour cells) are metabolic and genetically heterogeneous. There is now special interest in unravelling the mechanisms that allow the reminiscence of dormant tumour lesions that might be related to late disease progression and increased risk of recurrence. AMPK (AMP-activated protein kinase...