... under the Creative Commons Attribution License 4.0 (CC BY) . ATPase host-pathogen interactions innate immunity interferons RNA-binding proteins RIG-I preferentially selects dsRNA with 5′-triphosphate (5′ppp) at the end of the viral RNA (5′ppp dsRNA), and MDA5 selects a long dsRNA...

... of the RecA family recombinase SsoRadA from Saccharolobus solfataricus to determine its function in recombinase-mediated heteroduplex DNA formation. Wild-type SsoRadA protein and two ATPase mutant proteins were evaluated for the effects of three divalent metal cofactors. We found that unlike other archaeal...

... may provide a mechanism for the increased diabetes risk associated with a common channel variant and determines sensitivity to diazoxide. ATPase diabetes risk variant diazoxide K ATP channel ATP-sensitive potassium (K ATP ) channels are key transducers linking cellular metabolic...

...Gbenga A. Adenuga Ingestion of the mycotoxin Aflatoxin B 1 (AFB 1 ) by protein-undernourished Fischer F344 rats for twelve weeks resulted in significant ( p <0.05) increases in the proliferation of liver cells, reduced body weight and increased microsomal Ca 2+ -ATPase activity. Cyt. P 450...

...Walter S. Simonides; Marc H. M. Thelen; C. Gerard van der Linden; Alice Muller; Cornelis van Hardeveld Thyroid hormone increases the Ca 2+ -ATPase activity of the sarcoplasmic reticulum (SR) in skeletal muscle, thereby increasing the energy-turnover associated with Ca 2+ -cycling during contraction...

...Gbenga A. Adenuga The effect of protein undernutrition on the activity of the smoothendoplasmic reticulum (microsomal) Ca 2+ -ATPase (SERCA) wasinvestigated. After 12 weeks of ad libitum ingestion of low proteindiet (5% protein), a significant depression ( p <0.05) of liver ERCa 2+ -ATPase...

... rates. Here the influence of these solutes on sarcoplasmic reticulum and plasma membrane (Ca 2+ + Mg 2+ )ATPases is reviewed. The focus is on the changes induced by “perturbing” and “stabilizing” solutes at specific steps of the catalytic cycles of these enzymes, which can run forward (leading to ATP...

...Eduardo M. R. Reis; Carolyn W. Slayman; Sergio Verjovski-Almeida In recent years, expression of rabbit sarcoplasmic reticulum (SR) Ca 2+ -ATPase in heterologous systems has been a widely used strategy to study altered enzymes generated by site-directed mutagenesis. Various eukaryotic expression...

...Sérgio T. Ferreira; Tatiana Coelho-Sampaio Applications of intrinsic fluorescence measurements in the study of Ca 2+ -transport ATPases are reviewed. Since the initial reports showing that the fluorescence emission was sensitive to Ca 2+ binding, a substantial amount of work has focused on the use...

...Terry B. Rogers; Giuseppe Inesi; Robert Wade; W. J. Lederer Several reports have documented that thapsigargin is a potent inhibitor of the SR Ca 2+ ATPase isolated from cardiac or skeletal muscle. We have characterized the specificity of this agent in intact rat cardiac myocytes using cells...

... 2+ ATPase of sarcoplasmic reticulum (SR) includes an extramembranous globular head which is connected through a stalk to a membrane bound region. Cooperative binding of two calcium ions occurs sequentially, within a channel formed by four clustered helices within the membrane bound region...

...Anthony N. Martonosi Electron crystallographic studies on membrane crystals of Ca 2+ -ATPase reveal different patterns of ATPase-ATPase interactions depending on enzyme conformation. Physiologically relevant changes in Ca 2+ concentration and membrane potential affect these interactions. Ca 2...

...Anthony G. Lee; Kate A. Dalton; Richard C. Duggleby; J. Malcolm East; Anthony P. Starling Effects of lipid structure on the function of the Ca 2+ -ATPase of skeletal muscle of sarcoplasmic reticulum are reviewed. Binding of phospholipids to the ATPase shows little specificity. Phosphatidylcholines...

... and physical reactions. 14 9 1995 © 1995 Plenum Publishing Corporation 1995 ATPase calcium transport Bioscience Reports, Vol. 15, No. 5, 1995 REVIEW The Mechanism of Coupling Chemical and Physical Reactions by the Calcium ATPase of Sarcoplasmic Reticulum and Other Coupled Vectorial...

...Tohru Kanazawa; Hiroshi Suzuki; Takashi Daiho; Kazuo Yamasaki Changes in the fluoresence of N -acetyl- N ′-(5-sulfo-1-naphthyl)ethylenediamine (EDANS), being attached to Cys-674 of sarcoplasmic reticulum Ca 2+ -ATPase without affecting the catalytic activity, as well as changes in the intrinsic...

...Elisabeth Mintz; Florent Guillain We propose an overview of the mechanism of Ca 2+ transport through the sarcoplasmic reticulum membrane via the Ca 2+ -ATPase. We describe cytoplasmic calcium binding, calcium occlusion in the membrane and lumenal calcium dissociation. A channel-like structure...

... of disease. © 1991 Plenum Publishing Corporation 1991 membrane mitochondria transport chemiosmotics ATPase channels synaptic junctions neurotransmitters hormones P-glycoprotein multi-drug resistance antibiotics ionophores oxidative phosphorylation cardiac glycosides mitochondrial...