... a certain degree of specificity towards amyloid deposits makes themselves important candidates for the treatment of Alzheimer’s disease. Furthermore, nanotechnology has been used extensively to overcome several pertinent issues like drug-resistance phenomenon, side effects of conventional drugs and targeted...

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Aβ Alzheimer's disease BACE1 miR-15b NF-κB The Editorial Office has...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alzheimer's disease disease models neurodegeneration tau protein tauopathy western blot Tau is a neuronal, microtubule-associated protein (MAP) responsible for controlling the stabilization...

...Sonia Sanz Muñoz; Brett Garner; Lezanne Ooi APOE ε4 is the major genetic risk factor for Alzheimer’s disease (AD). A precise role for apolipoprotein E (apoE) in the pathogenesis of the disease remains unclear in part due to its expression in multiple cell types of the brain. APOE is highly...

...Hai Yuan; Lingling Du; Pingping Ge Complement receptor 1 (CR1) plays an important role in the development of sporadic Alzheimer’s disease (SAD) in Caucasians. However, the influence of CR1 (rs6656401A/G and rs3818361T/C) genetic polymorphisms on the risk of SAD remains controversial. A meta...

...Wanru Xu; Kai Li; Qian Fan; Biyun Zong; Ling Han Background: Alzheimer’s disease (AD), which has no effective drugs to delay or prevent its progression, is a multifactorial complex neurodegenerative disease. Long non-coding RNA SOX21 antisense RNA1 (SOX21-AS1) is associated with the development...

...Mahdi Rahaie; Saman Khayat Noroozi Multiplex assays for detection of biomarkers, provide advantageous analyses of different factors related to diagnoses of diseases. The Alzheimer’s disease (AD) is one of the most common disease in old people in societies which is increasing, significantly. A group...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alzheimer’s disease amyloid-β free radical Mangiferin SAMP8 Alzheimer’s disease (AD), also known as senile...

...Qiong Zhou; Lian Luo; Xiaohang Wang; Xiang Li Background and objective: Deregulation of the expression of amyloid precursor protein (APP) can lead to the development of Alzheimer’s disease (AD). Recent studies have shown that many single nucleotide polymorphisms (SNPs) in the 3′ untranslated region...

... to play a role in the development of various diseases [ 3 ]. In particular, apoE4 is a major causative factor of sporadic late-onset Alzheimer’s disease (AD) and its frequency is markedly increased in AD [ 4 ]. On the other hand, in another study, apoE4 was not present in approximately 30% of the patients...

...Ping Sun; Jun-Bo Yin; Li-Hua Liu; Jian Guo; Sheng-Hai Wang; Chun-Hui Qu; Chun-Xia Wang The aim of the present study was to understand the possible role of the Dihydromyricetin (DHM) in Alzheimer’s disease (AD) rat model through regulation of the AMPK/SIRT1 signaling pathway. Rats were divided...

...Juan Li; Haitao Wang Alzheimer’s disease (AD) is the multifactorial neurodegenerative disorder causing progressive memory loss and cognitive impairment. The aberrant accumulation of amyloid-β (Aβ) and neuroinflammation are two major events in AD. BACE1 is required for the cleavage of amyloid...

... developed an animal model presenting both Alzheimer’s disease (AD) and type 2 diabetes (T2D), by crossing APP/PS1 mice (AD model) with streptozotocin (STZ)-treated mice (a T2D model). Neuronal apoptosis was detected by TUNEL staining and the expression levels of apoptosis-related proteins were examined...

...Huajie Li; Jian Wu; Linfeng Zhu; Luolin Sha; Song Yang; Jiang Wei; Lei Ji; Xiaochun Tang; Keshi Mao; Liping Cao; Ning Wei; Wei Xie; Zhilong Yang Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying...

... work has shown that the intracellular domain of the amyloid precursor protein (APP), a molecule central to the aetiology of Alzheimer's disease binds to VAC14 and enhances PIKfyve function. In the present study, we utilize this recent advance to create an easy-to-use tool for increasing PIKfyve...

...Hongyun Li; Tim Karl; Brett Garner ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain. Recent genome-wide association studies (GWAS) have identified ABCA7 single nucleotide polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk, however, the mechanisms by which...

... sensitivity to changes in mtMP than TMRM. This multi-sensor system measured mitochondrial parameters in the brain of transgenic mice that model Alzheimer's disease (AD), because mitochondrial dysfunction is believed to be a primary event in the pathogenesis of AD. The coupled and maximal respiration...

...Genadiy Fonar; Abraham O. Samson Alzheimer's disease is the most common neurodegenerative disorder in the world. Its most significant symptoms are memory loss and decrease in cognition. Alzheimer's disease is characterized by aggregation of two proteins in the brain namely Aβ (amyloid β) and tau...

... in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in neurodegeneration?” is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic...

... of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene–environment interplay including, where implicated, mitochondrial genes. © 2006 Springer Science+Business Media, LLC...

... signaling in neurodegenerative and hyperproliferative diseases might impinge on the same molecular mechanisms, different pharmacological outcomes are required. Here we review recent developments on the understanding of the role of Wnt signaling in Alzheimer's disease and CNS tumors, and identify possible...

... Publishing Corporation 1986 SAF amyloid fibril protein Alzheimer's disease systemic amyloidosis Bioscience Reports, Vol. 6, No. 5, 1986 Scrapie-Associated Fibrils (SAF) Purification Method Yields Amyloid Proteins from Systemic and Cerebral Amyloidosis Tetsuyuki Kitamoto, l'3 Kohtaro Hikita,1...