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Keywords: Alzheimers disease
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Articles

FAD-deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation

Open Access
Sudipta Panja, David Siegel, Simonetta Camandola, Rafael de Cabo, David Ross, Krishna M.G. Mallela
Journal: Bioscience Reports
Biosci Rep (2022) 42 (11): BSR20220643.
https://doi.org/10.1042/BSR20220643
Published: 14 November 2022
...Sudipta Panja; David Siegel; Simonetta Camandola; Rafael de Cabo; David Ross; Krishna M.G. Mallela Alzheimer’s disease (AD) is one of the most prominent neurodegenerative diseases. Results from animal and cellular models suggest that FAD-deficient forms of NAD(P)H quinone oxidoreductase 1 (NQO1...
View articletitled, FAD-deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation
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Articles

Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau

Open Access
Marianna Hellén, Arnab Bhattacharjee, Riikka-Liisa Uronen, Henri J. Huttunen
Journal: Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20210148.
https://doi.org/10.1042/BSR20210148
Published: 05 August 2021
...Marianna Hellén; Arnab Bhattacharjee; Riikka-Liisa Uronen; Henri J. Huttunen Misfolded, pathological tau protein propagates from cell to cell causing neuronal degeneration in Alzheimer’s disease and other tauopathies. The molecular mechanisms of this process have remained elusive. Unconventional...
View articletitled, Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau
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Articles

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

Open Access
David A. Hicks, Alys C. Jones, Stuart M. Pickering-Brown, Nigel M. Hooper
Journal: Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20200435.
https://doi.org/10.1042/BSR20200435
Published: 28 April 2020
...David A. Hicks; Alys C. Jones; Stuart M. Pickering-Brown; Nigel M. Hooper Alzheimer’s disease (AD) is a neurodegenerative condition, of which one of the cardinal pathological hallmarks is the extracellular accumulation of amyloid β (Aβ) peptides. These peptides are generated via proteolysis...
View articletitled, The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
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Articles

Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier

Open Access
Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20193629.
https://doi.org/10.1042/BSR20193629
Published: 20 February 2020
...Yanchao Liu; Shujuan Zhang; Xiaoguang Li; Enjie Liu; Xin Wang; Qiuzhi Zhou; Jinwang Ye; Jian-Zhi Wang Abnormal aggregation of pathological tau protein is a neuropathological feature of Alzheimer’s disease (AD). In the AD patients, the abnormal tau accumulation first appeared in entorhinal cortex...
View articletitled, Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier
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Includes: Supplementary data