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Keywords: Antithrombin
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Articles

Protein disulfide isomerase uses thrombin–antithrombin complex as a template to bind its target protein and alter the blood coagulation rates

Abdul Burhan Khan, Urfi Siddiqui, Sana Fatima, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri
Journal: Bioscience Reports
Biosci Rep (2024) 44 (5): BSR20231540.
https://doi.org/10.1042/BSR20231540
Published: 15 May 2024
..., the PDI variants that increase the PDI activity (H399R) decrease, and the variant with low activity (C53A) increases the blood coagulation time. An SDS-PAGE and Western blot analysis showed that the PDI does not form a stable complex with either thrombin or antithrombin (ATIII) but it uses the ATIII...
View article titled, Protein disulfide isomerase uses thrombin–<span class="search-highlight">antithrombin</span> complex as a template to bind its target protein and alter the blood coagulation rates
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Includes: Supplementary data
Articles

Trehalose: is it a potential inhibitor of antithrombin polymerization?

Irene Martínez-Martínez
Journal: Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190567.
https://doi.org/10.1042/BSR20190567
Published: 18 June 2019
.... [ Biosci. Rep . (2019) 5 , 39] studies the role of trehalose in the prevention of the polymerization of antithrombin, which belongs to the serpin superfamily. The main consequence of the antithrombin polymerization is the increased thrombotic risk, since antithrombin is the main inhibitor...
View article titled, Trehalose: is it a potential inhibitor of <span class="search-highlight">antithrombin</span> polymerization?
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Articles

Deciphering the role of trehalose in hindering antithrombin polymerization

Asma Naseem, Mohammad Sazzad Khan, Hashim Ali, Irshad Ahmad, Mohamad Aman Jairajpuri
Journal: Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20182259.
https://doi.org/10.1042/BSR20182259
Published: 05 April 2019
...Asma Naseem; Mohammad Sazzad Khan; Hashim Ali; Irshad Ahmad; Mohamad Aman Jairajpuri Serine protease inhibitors (serpins) family have a complex mechanism of inhibition that requires a large scale conformational change. Antithrombin (AT), a member of serpin superfamily serves as a key regulator...
View article titled, Deciphering the role of trehalose in hindering <span class="search-highlight">antithrombin</span> polymerization
Open the PDF for Deciphering the role of trehalose in hindering <span class="search-highlight">antithrombin</span> polymerization in another window
Includes: Supplementary data