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Keyword: Apoptosis
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Journal Articles
Bioscience Reports BSR20191252.
Published: 14 October 2019
... infiltration in AAA aortic membrane as evidenced by elevated levels of MCP1, IL-1β and NF-κB, as well as HE staining. The elasticity of aortic tunica media was impaired along with multiple apoptosis of vascular smooth muscle cells (VSMCs) in Ang-II-induced aneurysmal mouse. In vitro Ang-II administration of...
Journal Articles
Bioscience Reports (11 October 2019) 39 (10): BSR20191348.
Published: 11 October 2019
...-expressions of miR-182 can increase apoptosis rate. Luciferase reporter assay revealed that CRR9 was a downstream gene of miR-182. Reintroduction of CRR9 abolished miR-182-induced LSCC cell growth inhibition. In animal models, over-expressions of miR-182 can reduce tumor weight and promote apoptosis...
Includes: Supplementary data
Journal Articles
Bioscience Reports (11 October 2019) 39 (10): BSR20190828.
Published: 11 October 2019
... showed that YLT-LL-11 inhibited the proliferation of a DLBCL cell line OCI-LY10 via inducing G0/G1 cell cycle arrest with regulation of the cyclin-dependent kinases (CDKs) expression. Furthermore, YLT-LL-11 facilitated OCI-LY10 cell apoptosis by up-regulation of pro-apoptotic protein BAX and down...
Includes: Supplementary data
Journal Articles
Bioscience Reports (16 September 2019) 39 (9): BSR20182193.
Published: 16 September 2019
... MUC1 gene silencing on proliferation, DNA replication, cell cycle distribution, apoptosis, colony formation ability, epithelial-mesenchymal transition (EMT), invasion, and migration of OSCC cells. We first found higher positive rate of MUC1 and Slug expression in OSCC tissues. Next, it was determined...
Journal Articles
Bioscience Reports (13 September 2019) 39 (9): BSR20191649.
Published: 13 September 2019
... correlated with LOXL1-AS. LOXL1-AS overexpression mediated the up-regulation of Giver in human aortic smooth muscle cells, while Giver overexpression failed to significantly affect LOXL1-AS. LOXL1-AS and Giver overexpression resulted in promoted proliferation and inhibited apoptosis of HAOSMC. Giver...
Journal Articles
Bioscience Reports (9 September 2019) 39 (9): BSR20190503.
Published: 09 September 2019
... revealed that ENO1 was critical for the growth and proliferation of BC cells. ENO1 over-expression also promoted the proliferation of SV-HUC-1 cells. At the molecular level, the cell cycle and apoptosis related genes were regulated by ENO1. β-catenin expression was positively regulated by ENO1. Furthermore...
Journal Articles
Bioscience Reports (6 September 2019) 39 (9): BSR20190654.
Published: 06 September 2019
... and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the...
Journal Articles
Bioscience Reports (28 August 2019) 39 (8): BSR20190590.
Published: 28 August 2019
..., apoptosis, cancer stem cells regulation, epithelial–mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity. * These authors...
Journal Articles
Bioscience Reports (23 August 2019) 39 (8): BSR20170770.
Published: 23 August 2019
.... In the present study, we investigated the possible role of a novel autophagy regulator, activating molecule in beclin1-regulated autophagy1 (Ambra1), a novel ATG gene in the sensitivity or PCa cells to cisplatin. We explored the regulation by the Ambra1 manipulation on the induction of apoptosis and...
Journal Articles
Bioscience Reports (19 August 2019) 39 (8): BSR20190109.
Published: 19 August 2019
... control, GLP-1 has been reported to exert functions in a variety of tissues on modulation of cell proliferation, differentiation, and apoptosis. However, little is known regarding the effects of GLP-1 on nucleus pulposus cells (NPCs). In the present study, we investigated the effects of liraglutide (LIR...
Journal Articles
Bioscience Reports (19 August 2019) 39 (8): BSR20191182.
Published: 19 August 2019
...Lin Lou; Guo Chen; Bing Zhong; Feng Liu Lycium barbarum polysaccharide (LBP) has a variety of pharmacological and biological activities such as anti-inflammatory, antioxidation, anti-apoptosis, immune regulation and other pharmacological effects; however, the effect of LBP on infantile hemangioma...
Journal Articles
Bioscience Reports (15 August 2019) 39 (8): BSR20190689.
Published: 15 August 2019
... demonstrated that pretreatment of ARPE-19 cells with delphinidin (25, 50, and 100 μg/ml) significantly increased cell viability and reduced the apoptosis from H 2 O 2 (0.5 mM)-induced oxidative stress in a concentration-dependent manner, which was achieved by the inhibition of Bax, cytochrome c , and caspase-3...
Journal Articles
Bioscience Reports (13 August 2019) 39 (8): BSR20190405.
Published: 13 August 2019
... adenovirus coding cDNA of PKG II to increase PKG II expression and l -Arg was applied to activate this kinase. CCK8 assay, Transwell migration and TUNEL assay were applied to detect the proliferation, migration and apoptosis of the OC cells, respectively. Western blotting was used to detect the level of...
Includes: Supplementary data
Journal Articles
Bioscience Reports (13 August 2019) 39 (8): BSR20190720.
Published: 13 August 2019
...Madhumitha Kedhari Sundaram; Ritu Raina; Nazia Afroze; Khuloud Bajbouj; Mawieh Hamad; Shafiul Haque; Arif Hussain Cancer cells have the unique ability to overcome natural defense mechanisms, undergo unchecked proliferation and evade apoptosis. While chemotherapeutic drugs address this, they are...
Journal Articles
Bioscience Reports (13 August 2019) 39 (8): BSR20190548.
Published: 13 August 2019
... apoptosis rate were determined by Cell Counting Kit-8 (CCK-8) and flow cytometry, respectively. We additionally measured the phosphorylation levels of p38 and p65. We found that the injection of miR-191-5p mimic could observably inhibit renal injury scores, and inhibit inflammatory cytokine productions and...
Includes: Supplementary data
Journal Articles
Bioscience Reports (5 August 2019) 39 (8): BSR20191124.
Published: 05 August 2019
... apoptosis and regulated the expression of apoptosis-associated proteins. In conclusion, these results indicate that by dysregulating translational initiation, eIF3c plays an important role in the proliferation and survival of human ovarian cancer cells. These results should provide experimental directions...
Includes: Supplementary data
Journal Articles
Bioscience Reports BSR20181000.
Published: 02 August 2019
..., and Annexin-V-R-PE assay for apoptosis of different cell lines.</p> <p>Results: Highly expressed miR-21-5p and lowly expressed MAPK10 were selected for subsequent experiments, according to the microarray analysis. RT-qPCR showed that the expression of MAPK10 in breast cancer tissues was...
Journal Articles
Bioscience Reports (2 August 2019) 39 (8): BSR20190788.
Published: 02 August 2019
...Xiaonan Zhang; Shaoyang Dong; Qiujin Jia; Ao Zhang; Yanyang Li; Yaping Zhu; Shichao Lv; Junping Zhang Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis, cardiac hypertrophy, and myocardial fibrosis, which is often caused by various cardiovascular diseases...
Journal Articles
Bioscience Reports (30 July 2019) 39 (7): BSR20182274.
Published: 30 July 2019
... hepatocellular carcinoma A3 (EPHA3) on endometriosis, with emphasis on the autophagy and apoptosis of macrophages via inhibition of the mammalian target of rapamycin (mTOR) signaling pathway. Methods: The mouse models of endometriosis were established followed by culturing the macrophages and macrophage...
Journal Articles
Bioscience Reports (26 July 2019) 39 (7): BSR20181794.
Published: 26 July 2019
... analyzed. After transfection with sh-LINC01220 and pcDNA-MAPK11 (mitogen-activated protein kinase) in EC cells, proliferative, colony formation abilities and apoptosis were determined by cell counting kit-8 (CCK-8), colony formation assay and flow cytometry, respectively. Western blot was conducted to...
Journal Articles
Bioscience Reports (26 July 2019) 39 (7): BSR20191050.
Published: 26 July 2019
... (lncRNA) small nucleolar RNA host gene 1 (SNHG1) and to elucidate the underlying mechanisms. We found that DOX treatment led to severe damage in AC16 cells through decreasing cell viability and increasing cell apoptosis. DOX treatment also reduced the expression of SNHG1 in AC16 cells, and overexpression...
Journal Articles
Bioscience Reports (23 July 2019) 39 (7): BSR20190094.
Published: 23 July 2019
... (PRA) requires more attention. Hence, the current study aimed to examine whether mifepristone, a PRA, influences the autophagy and apoptosis of uterine leiomyoma cells. Primary uterine leiomyoma cells were collected from 36 patients diagnosed with uterine leiomyoma to establish PR-M-positive (PR-M...
Journal Articles
Bioscience Reports (12 July 2019) 39 (7): BSR20191210.
Published: 12 July 2019
... performed to detect the effects of LINC00982 on the cell proliferation and migration in PTC cells. Furthermore, western blot assay was used to measure the alteration expression levels of apoptosis relative proteins and the relative protein involved phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway...
Journal Articles
Bioscience Reports (8 July 2019) 39 (7): BSR20190853.
Published: 08 July 2019
...Lizhen Shan; Di Yang; Di Yang; Danjie Zhu; Fabo Feng; Xiaolin Li Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. A high glucose niche-mediated disc cell apoptosis is an implicate causative factor for the spine degenerative diseases related with DM. However...
Journal Articles
Bioscience Reports (25 June 2019) 39 (6): BSR20181826.
Published: 25 June 2019
... demonstrated that knockdown of GLS induced apoptosis and cell cycle arrest. Moreover, we observed that the expressions of Bax were increased while the levels of cyclinD1 and Bcl-2 were decreased after knockdown of GLS in PCa cells. Importantly, through Western blot analysis, we identified that GLS knockdown...
Includes: Supplementary data
Journal Articles
Bioscience Reports (25 June 2019) 39 (6): BSR20181367.
Published: 25 June 2019
... role of RMRP in I/R injury, the effects of RMRP knockdown on oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced injury in SH-SY5Y cells were evaluated. The effect of OGD/R administration on the expression of RMRP and apoptosis in SH-SY5Y cells, and the effect of RMRP suppression by siRNA on the...
Journal Articles
Bioscience Reports (14 June 2019) 39 (6): BSR20190167.
Published: 14 June 2019
... activity and apoptosis-inducing effect, as well as the underlying mechanism. ALE had an excellent capability of inhibiting spore germination and mycelial growth of Penicillium chrysogenum observed by inverted microscope and scanning electron microscopy. XTT colorimetric assay indicated ALE could reduce the...
Includes: Supplementary data
Journal Articles
Bioscience Reports (10 June 2019) 39 (6): BSR20190696.
Published: 10 June 2019
... treatments. The significant decrease in X-linked inhibitor of apoptosis protein (XIAP) and increase in caspase-3 detected in our study suggested that the enhancement of apoptosis is mediated by XIAP/caspase-3 pathway, which was further confirmed by examining the downstream effectors of caspase-3, COX-2, PARP...
Journal Articles
Bioscience Reports (7 June 2019) 39 (6): BSR20190502.
Published: 07 June 2019
... various concentrations of EECR. Cell proliferation was examined using Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell apoptosis and cell cycle were detected by flow cytometry. Apoptosis- and autophagy-related protein expression was detected by Western blot. EECR inhibits the proliferation of...
Journal Articles
Bioscience Reports (7 June 2019) 39 (6): BSR20182443.
Published: 07 June 2019
... experiments, LINC00460 was overexpressed in NSCLC cell lines under nicotine stimulation. Nicotine could relieve the effect of LINC00460 knockdown on NSCLC cell proliferation, migration and apoptosis. The same influence was observed on PI3K/Akt signaling pathway. Conclusions : In summary, this is the first...
Journal Articles
Bioscience Reports (4 June 2019) 39 (6): BSR20190425.
Published: 04 June 2019
... proliferation and apoptosis were assessed using the shRNA method for both in vitro and in vivo experiments. Potential target genes of HSDL2 were determined via bioinformatics analyses and Western blotting. HSDL2 was up-regulated in PTC tissues and cell lines compared with the controls (all P <0.05...
Includes: Supplementary data
Journal Articles
Bioscience Reports (4 June 2019) 39 (6): BSR20182433.
Published: 04 June 2019
... inhibited proliferation and induced apoptosis in NSCLC cell lines. The migration and invasion of NSCLC cells were also suppressed by circVANGL1 knockdown. In addition, we predicted that circVANGL1 might serve as a competing endogenous RNA (ceRNA), becoming a sink for miR-195, thereby modulating the...
Journal Articles
Bioscience Reports (24 May 2019) 39 (5): BSR20181144.
Published: 24 May 2019
...Kun Chen; Liang Zhang The aim of the present study was to investigate whether the use of drug-loaded microbubbles combined with ultrasound promotes the apoptosis of cancer cells by regulating B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein (Bax) expression. Adriamycin-loaded PLGA...
Journal Articles
Bioscience Reports (21 May 2019) 39 (5): BSR20190225.
Published: 21 May 2019
... study, we explored the effects of PA on proliferation and apoptosis of H9c2 cardiomyocytes, and uncovered the signaling pathways involved in PA toxicity. Our study revealed induction of both oxidative and endoplasmic reticulum (ER) stresses and exacerbation of apoptosis in PA-treated H9c2 cells...
Includes: Supplementary data
Journal Articles
Bioscience Reports (17 May 2019) 39 (5): BSR20181919.
Published: 17 May 2019
... differentially expressed circRNAs. The CCK-8 and flow cytometry were performed to measure the cell viability and apoptosis in breast cancer cells. Gene and protein expression were assayed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blotting, respectively. Results...
Journal Articles
Bioscience Reports (15 May 2019) 39 (5): BSR20182321.
Published: 15 May 2019
..., migration, invasion and apoptosis. Our previous study has identified 29 miRNAs that are highly expressed in gastric cancer stem cells. One of these miRNAs, miR-1915-3p, has shown great potential as a diagnostic and prognostic biomarker for the cancers in liver, colon and thyroid, as well as in immune and...
Journal Articles
Bioscience Reports (14 May 2019) 39 (5): BSR20182454.
Published: 14 May 2019
... significantly and positive correlated only in osteoarthritis patients. Overexpression of lncRNA CASC2 led to up-regulated expression of IL-17 in cells of human chondrocyte cell line CHON-001 (ATCC ® CRL-2846™). In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis...
Journal Articles
Bioscience Reports (10 May 2019) 39 (5): BSR20190469.
Published: 10 May 2019
... be due to the induction of apoptosis. Moreover Transwell assay revealed that L-securinine significantly inhibited the cell migration/invasion ability of DU145 cells. Furthermore, results of western blotting showed that the involvement of mitochondrial apoptotic pathway in the L-securinine-induced...
Journal Articles
Bioscience Reports (2 May 2019) 39 (5): BSR20181464.
Published: 02 May 2019
... behavioral activities. In recent years, many studies have reported the effects of long-term (more than 6 weeks) illumination on ovarian growth and development. In the present study, we observed the damage, repair and apoptosis of ovarian DNA in a short period of illumination. The results showed that, in...
Journal Articles
Bioscience Reports (2 May 2019) 39 (5): BSR20181196.
Published: 02 May 2019
... induced apoptosis. Therefore, miR–517a acts an oncogenic miRNA that promotes tumor progression in glioma, and thus may become a promising therapeutic candidate for glioma. Correspondence: Cheng-li Du ( duchengli6688@sina.com ) 18 07 2018 29 01 2019 15 03 2019 08 04 2019...
Journal Articles
Bioscience Reports (30 April 2019) 39 (4): BSR20190150.
Published: 30 April 2019
...Zi-Yuan Nie; Xiao-Jun Liu; Ying Zhan; Meng-Han Liu; Xiao-Yan Zhang; Zi-Ye Li; Ya-Qiong Lu; Jian-Min Luo; Jian-Min Luo; Lin Yang microRNAs (miRNA), as tumor suppressors or oncogenes, are involved in modulating cancer cell behavior, including cell proliferation and apoptosis. The miR-140-5p acts as...
Journal Articles
Bioscience Reports (26 April 2019) 39 (4): BSR20190410.
Published: 26 April 2019
... of MNNG and U2OS cells, while inhibiting their apoptosis. In contrast, the knockdown of miR-92a effectively reversed these cellular biological behaviors. Furthermore, bioinformatics analysis indicated that Dickkopf-related protein 3 (DKK3) was a possible target of miR-92a. Subsequently, negative...
Includes: Supplementary data
Journal Articles
Bioscience Reports (12 April 2019) 39 (4): BSR20182266.
Published: 12 April 2019
..., while its resistance to TNF-α-killing remains largely unexplored. In this assay, we first found cellular inhibitor of apoptosis (cIAP1) overexpressed in GBC tissues and the roles in promoting the proliferation and migration of GBC in vitro as its homology cIAP2 does. Then how GBC cell survives TNF-α...
Journal Articles
Bioscience Reports (5 April 2019) 39 (4): BSR20190040.
Published: 05 April 2019
... of the patients with leukemia. Lentivirus-mediated knockdown of USP39 repressed the proliferation and colony formation of human leukemia cell lines HL-60 and Jurkat cells. Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells. In addition, our...
Includes: Supplementary data
Journal Articles
Bioscience Reports (2 April 2019) 39 (4): BSR20190170.
Published: 02 April 2019
... or the high glucose (0.2 M) culture medium. OP-1 was added into the high glucose culture medium to investigate whether its has some protective effects against degenerative changes of NP cells in the high glucose culture. NP cell apoptosis ratio, caspase-3/9 activity, expression of apoptosis-related...
Journal Articles
Bioscience Reports (29 March 2019) 39 (3): BSR20182097.
Published: 29 March 2019
... overexpression mediated miR-145-5p up-regulation in PC cells, while miR-145-5p overexpression did not significantly affect BRE-AS1. Overexpression of BRE-AS1 and miR-145-5p led to inhibited proliferation and promoted apoptosis of PC cells. miR-145-5p inhibitor attenuated the effects of BRE-AS1 overexpression on...
Journal Articles
Bioscience Reports (29 March 2019) 39 (3): BSR20182462.
Published: 29 March 2019
...Qing Xu; Haolin Fang; Liang Zhao; Cunxin Zhang; Luo Zhang; Baofang Tian Mechanical overload is a risk factor of disc degeneration. It can induce disc degeneration through mediating cell apoptosis. Mechano growth factor (MGF) has been reported to inhibit mechanical overload-induced apoptosis of...
Journal Articles
Bioscience Reports (26 March 2019) 39 (3): BSR20190043.
Published: 26 March 2019
...Yanhai Jiang; Zhijie Xie; Jinying Yu; Lianqiang Fu Nucleus pulposus (NP) cell apoptosis is a classical cellular character during intervertebral disc degeneration (IDD). Previous studies have shown that inflammatory cytokine-induced NP cell apoptosis plays an important role in disc degeneration...
Journal Articles
Bioscience Reports (22 March 2019) 39 (3): BSR20181916.
Published: 22 March 2019
... Nexturastat A (NexA), a novel selective HDAC6 inhibitor. We found that NexA impaired MM cells viability in a dose- and time-dependent manner. NexA also provoked a cell cycle arrest at the G1 phase in MM cells . Furthermore, NexA promoted apoptosis of MM cells via transcriptional activation of the p21 promoter...
Journal Articles
Bioscience Reports (19 February 2019) 39 (2): BSR20181345.
Published: 19 February 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy apoptosis mutant p53 SAHA The p53 tumor suppressor protein has a central role in cell homeostasis due to its involvement in many pathways that regulate cell cycle arrest and proliferation, cell...
Includes: Supplementary data