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Keywords: Autophagy
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Articles
Biosci Rep (2021) 41 (10): BSR20211056.
Published: 06 October 2021
.../M phase in H1299 cells. Mitochondria-mediated apoptosis was induced in A549 cells but not in H1299 cells after treatment with digoxin. Moreover, digoxin inhibited the migration, invasion, adhesion and epithelial–mesenchymal transition of A549 and H1299 cells. Autophagy was induced in both cell lines...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (8): BSR20211098.
Published: 20 August 2021
...Samuel Chuah; Valerie Chew Uveal Melanoma (UM) is a rare cancer deriving from melanocytes within the uvea. It has a high rate of metastasis, especially to the liver, and a poor prognosis thereafter. Autophagy, an intracellular programmed digestive process, has been associated with the development...
Articles
Biosci Rep (2021) BSR20210640.
Published: 16 August 2021
... healing. However, little is known about the mechanism underlying high glucose (HG)-induced decrease of tendon fibroblasts viability. In the present study the rat models of DFU were established, and collagen deposition, autophagy activation and cell apoptosis in tendon tissues were assessed using...
Articles
Biosci Rep (2021) 41 (6): BSR-2017-0803_RET.
Published: 14 June 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alveolar epithelial cells Autophagy Chronic obstructive pulmonary disease...
Articles
Biosci Rep (2021) 41 (5): BSR-20171691_EOC.
Published: 14 May 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy curcumin Osteoarthritis The Editorial Office has been made...
Articles
Biosci Rep (2021) 41 (5): BSR-20160523_RET.
Published: 14 May 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 This Retraction...
Articles
Biosci Rep (2021) 41 (5): BSR20203362.
Published: 04 May 2021
..., our data demonstrated that Shensu IV can prevent glomerular podocyte injury in nephrotic rats and puromycin-treated podocytes, likely via promoting lncRNA H19/DIRAS3-regulated autophagy. Correspondence: Guoqing Wu ( wuguoqing6129@163.com ) or Weiguo Song ( weiguosong610@163.com ) 06 11...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20191041_EOC.
Published: 07 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy mTORC ovarian cancer PD-L1 The Editorial Office has been...
Articles
Biosci Rep (2021) 41 (4): BSR-20190094_EOC.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis autophagy mifepristone progesterone receptor antagonist...
Articles
Biosci Rep (2021) 41 (3): BSR20203812.
Published: 19 March 2021
...Zhuotao Zheng; Lingyue Zhang; Zewei Tu; Yan Deng; Xiaolong Yin Autophagy is involved in cancer initiation and progression but its role in uveal melanoma (UM) was rarely investigated. Herein, we built an autophagy-related gene (ARG) risk model of UM patients by univariate Cox regression and least...
Articles
Biosci Rep (2021) 41 (1): BSR20200842.
Published: 27 January 2021
... the prosurvival autophagy so as to improve the antitumor efficiency of chemotherapeutic drugs on GC cells. Meanwhile, transcript level of DDIT3, which is an apoptosis-related tumor suppressor gene downstream of mTORC1, was regulated by omeprazole-induced FTO silence through an m 6 A-dependent mechanism...
Articles
Biosci Rep (2021) 41 (1): BSR20203231.
Published: 15 January 2021
...Wenfang Xu; Wenke Guo; Ping Lu; Duan Ma; Lei Liu; Fudong Yu The poor prognosis of hepatocellular carcinoma (HCC) calls for the development of accurate prognostic models. The growing number of studies indicating a correlation between autophagy activity and HCC indicates there is a commitment...
Articles
Biosci Rep (2020) 40 (11): BSR20200661.
Published: 19 November 2020
... that Sop significantly mitigated TAC-induced heart dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis. Mechanistically, Sop treatment induced a remarkable activation of AMPK/mTORC1-autophagy cascade following sustained hypertrophic stimulation. Importantly, the protective effect of Sop was largely...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (9): BSR20201918.
Published: 28 September 2020
... could inhibit proliferation, induce G 2 /M cell cycle arrest and apoptosis, and could inhibit autophagy of acute leukemia cell lines in vitro . Thus, our findings suggest that SOV could effectively suppress the growth of acute leukemia HL60 cells and HL60/A cells through the regulations of proliferation...
Articles
Biosci Rep (2020) 40 (9): BSR20194515.
Published: 18 September 2020
... the activation of caspase-9 and PARP, which are the apoptotic signaling pathway proteins activated by hTNF-α. Meanwhile, lysosome autophagy signaling pathways stimulated by hTNF-α were inhibited by FVH1-1, which down-regulated the expression of LC3II/LC3I and up-regulated the expression of P62, indicating...
Articles
Biosci Rep (2020) 40 (7): BSR-20170803_EOC.
Published: 27 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alveolar epithelial cells Apoptosis Autophagy Chronic obstructive...
Articles
Biosci Rep (2020) 40 (7): BSR-20160523_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 The Editorial...
Articles
Biosci Rep (2020) 40 (4): BSR20200905.
Published: 28 April 2020
...Anthony O. Fedele; Christopher G. Proud Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each cause...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20193006.
Published: 31 March 2020
...Xiaomin Liu; Xiaowen Zhao; Rong Cheng; Yusen Huang Purpose: Autophagic dysfunction and abnormal oxidative stress are associated with cataract. The purpose of the present study was to investigate the changes of cellular autophagy and oxidative stress and their association in lens epithelial cells...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20192620.
Published: 25 March 2020
... autophagy via regulation of MAPK/NF-κB signaling pathway in vivo and in vitro , and PAR2 can be considered as a potential candidate to treat OA. Correspondence: Chen Hui ( harrychen12@sina.com ) or Wei Jianjun ( weijianjun197608@163.com ) At present, autophagy has been found to be involved in many...
Articles
Biosci Rep (2020) 40 (1): BSR20193156.
Published: 24 January 2020
... NSCs markers, thus making cellular in vitro cell models essential. © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (12): BSR20191041.
Published: 20 December 2019
... of mTORC. In addition, PD-L1 promotes the autophagy of ovarian cancer cells by up-regulating the expression of BECN1, a crucial molecule involved in the regulation of autophagy. In conclusion, PD-L1 may provide a target for the development of a novel strategy for the treatment of ovarian cancer...
Articles
Biosci Rep (2019) 39 (12): BSR20192489.
Published: 06 December 2019
... agent due to its inhibitory effects on the proliferation of glioma cells in vitro and in vivo . However, the ability of IVM to induce autophagy and its role in glioma cell death remains unclear. The main objective of the present study was to explore autophagy induced by IVM in glioma U251 and C6 cells...
Articles
Biosci Rep (2019) 39 (12): BSR20191860.
Published: 04 December 2019
... II and p-AMPK expression. It was also found that CRA blunted cardiomyocyte hypertrophy and promoted autophagy in Angiotensin II (Ang II)-treated H9c2 cells. Moreover, to further verify whether CRA inhibits cardiac hypertrophy by the activation of autophagy, blockade of autophagy was achieved by CQ...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (10): BSR20190679.
Published: 21 October 2019
... but decrease the expression of ZEB2. BTXA could significantly inhibit the proliferation, cell cycle, and migration and promote apoptosis and autophagy of HSFBs; however, miR-1587 and miR-2392 inhibitors could reverse these effects of BTXA on HSFBs. Silencing ZEB2 could significantly attenuate the effects...
Articles
Biosci Rep (2019) 39 (9): BSR20191452.
Published: 06 September 2019
.... In the present study, we aimed to elucidate the anti-autophagy and anti-apoptosis effects of ginkgetin via nuclear factor κB (NF-κB)/p53 pathway in cerebral I/R rats. Methods : Rats were administrated 2-h occlusion of right middle cerebral artery before the 24-h reperfusion followed. There were three doses...
Articles
Biosci Rep (2019) 39 (8): BSR20170770.
Published: 23 August 2019
...Jie Liu; Zhiyuan Chen; Jia Guo; Lei Wang; Xiuheng Liu Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa...
Articles
Biosci Rep (2019) 39 (8): BSR20190578.
Published: 07 August 2019
... the cells were treated with 9 mM 4-PBA and/or CHOP-siRNA4, the apoptosis rate, ROS level, lysosome activity and expression of PARP, Caspase-12, Caspase-3, LC3, Beclin-1 and CHOP were significantly reduced. Conclusions: Autophagy reaction mediated by endoplasmic reticulum stress plays important rale...
Articles
Biosci Rep (2019) 39 (8): BSR20190788.
Published: 02 August 2019
... in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) is one of the most abundant miRNAs in the heart. In recent years, the study found that the miR-30 family can participate in VR through a variety of mechanisms, including autophagy, apoptosis...
Articles
Biosci Rep (2019) 39 (7): BSR20182274.
Published: 30 July 2019
... hepatocellular carcinoma A3 (EPHA3) on endometriosis, with emphasis on the autophagy and apoptosis of macrophages via inhibition of the mammalian target of rapamycin (mTOR) signaling pathway. Methods: The mouse models of endometriosis were established followed by culturing the macrophages and macrophage...
Articles
Biosci Rep (2019) 39 (7): BSR20190035.
Published: 23 July 2019
... that SMG damage and repair often occur with autophagy in the rat. However, no studies reported whether secretory inhibition and structural changes of SMG after BTXA injection is related with autophagy. The present study was carried out to explore the association between BTXA injection and autophagy in rat...
Articles
Biosci Rep (2019) 39 (7): BSR20190094.
Published: 23 July 2019
... (PRA) requires more attention. Hence, the current study aimed to examine whether mifepristone, a PRA, influences the autophagy and apoptosis of uterine leiomyoma cells. Primary uterine leiomyoma cells were collected from 36 patients diagnosed with uterine leiomyoma to establish PR-M-positive (PR-M...
Articles
Biosci Rep (2019) 39 (6): BSR20181367.
Published: 25 June 2019
... on the impairments of cells proliferation and mobility potential due to OGD/R administration were assessed in the current study. At the molecular level, the current study detected the expressions of indicators involved in autophagy and PI3K/Akt/mTOR-mediated apoptosis pathways. The OGD/R administration induced...
Articles
Biosci Rep (2019) 39 (6): BSR20190459.
Published: 20 June 2019
... carcinoma (LSCC). We aimed to investigate the effects of PHN on the proliferation and apoptosis of HEp-2 cells. In the present study, PHN alone showed little effect on HEp-2 cell proliferation and apoptosis. Subsequent tests showed that PHN could largely enhance the level of autophagy on HEp-2 cells...
Articles
Biosci Rep (2019) 39 (6): BSR20190502.
Published: 07 June 2019
... concentrations of EECR. Cell proliferation was examined using Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell apoptosis and cell cycle were detected by flow cytometry. Apoptosis- and autophagy-related protein expression was detected by Western blot. EECR inhibits the proliferation of TNBC cells...
Articles
Biosci Rep (2019) 39 (4): BSR20180650.
Published: 26 April 2019
... staining, and cardiac functions were calculated according to echocardiographic evaluation. Cell viability in cardiomyocytes was investigated by Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) release assays. Western blot was used to detect autophagy-related proteins including Beclin-1, LC3, p62...
Articles
Biosci Rep (2019) 39 (4): BSR20190163.
Published: 17 April 2019
... to investigate AF cell senescence under mechanical tension and the potential role of autophagy. Methods: Rat AF cells were cultured and experienced different magnitudes (5% elongation and 20% elongation) of mechanical tension for 12 days. Control AF cells were kept static. Cell proliferation, telomerase activity...
Articles
Biosci Rep (2019) 39 (2): BSR20181345.
Published: 19 February 2019
... for their ability to induce the degradation of mutp53 through the activation of autophagy. Here, we investigated the correlation between autophagy and mutp53 degradation induced by suberoylanilide hydroxamic acid (SAHA), an FDA-approved histone deacetylase inhibitor. In the human cancer lines MDA-MB-231 (mutp53...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (1): BSR20181707.
Published: 15 January 2019
... of chamaejasmine is newly discovered from Stellera chamaejasmine L. Our study focuses on investigating the effect of chamaejasmine on the cellular apoptosis, proliferation, autophagy, and the underlying mechanisms in MG-63. Methods: Our study investigated the concentration of chamaejasmine in MG-63 cells by MTT...
Articles
Biosci Rep (2019) 39 (1): BSR20181156.
Published: 03 January 2019
...Ruben Adrian Grosso; Paula Virginia Subirada Caldarone; María Cecilia Sánchez; Gustavo Alberto Chiabrando; María Isabel Colombo; Claudio Marcelo Fader Hemin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20181822.
Published: 30 November 2018
...Xiaokun Lin; Lei Han; Jialei Weng; Kelai Wang; Tongke Chen Objective To investigate the effect of Rapamycin on proliferation and autophagy in human neuroblastoma (NB) cell lines and to elucidate the possible mechanism. Methods NB cells were treated with different concentrations of Rapamycin. Cell...
Articles
Biosci Rep (2018) 38 (6): BSR20180876.
Published: 21 November 2018
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Acute renal injury Apoptosis Autophagy Contrast media mitochondrial injury Oxidative stress Contrast medium is used widely in many diagnostic and interventional procedures, and is a necessary component in modern...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20180516.
Published: 23 October 2018
...Qingqing Yin; Wei Feng; Xianjuan Shen; Shaoqing Ju Autophagy is an important process in endogenous substrate degradation by lysosomes within cells, with a degree of evolutionary conservation. Like apoptosis and cell senescence, cell autophagy is a very important biological phenomenon involving...
Articles
Biosci Rep (2018) 38 (4): BSR20170982.
Published: 18 July 2018
... can inhibit cardiac hypertrophy and block the development of heart failure by promoting autophagy. However, other investigators have demonstrated that overactive and dysregulated autophagy may also contribute to the onset and exacerbation of heart failure. Thus, a major goal of the present...
Articles
Biosci Rep (2018) 38 (4): BSR20180544.
Published: 06 July 2018
... homeostasis under oxidative damage and the potential mechanism. Rat NP cells were exposed to H 2 O 2 solution to create an oxidative damage. RSV and the 3-methyladenine (3-MA) were added along with the culture medium to respectively investigate the role of RSV and cellular autophagy. NP matrix synthesis...
Articles
Biosci Rep (2018) 38 (4): BSR20171691.
Published: 03 July 2018
...Guowang Zhang; Jiaqing Cao; Erzhu Yang; Bo Liang; Jianing Ding; Jiaming Liang; Jianguang Xu Reduced autophagy has been implied in chondrocyte death and osteoarthritis. Curcumin (Cur) owns therapeutic effect against osteoarthritis (OA) and enhances autophagy in various tumor cells. Whether...
Articles
Biosci Rep (2018) 38 (2): BSR20171669.
Published: 20 April 2018
...). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer autophagy Leucin Rich Repeat Kinase 2 (LRRK2) mammalian Target Of Rapamycin (mTOR) Parkinson...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (6): BSR20170803.
Published: 15 November 2017
...Yao Tang; Qi-Hang Cai; Yong-Jian Wang; Shao-Hua Fan; Zi-Feng Zhang; Meng-Qi Xiao; Jin-Yu Zhu; Dong-Mei Wu; Jun Lu; Yuan-Lin Zheng During the present study, we explored the protective effects of autophagy on endoplasmic reticulum (ER) stress (ERS) induced apoptosis belonging to alveolar epithelial...
Articles
Biosci Rep (2017) 37 (6): BSR20160523.
Published: 06 November 2017
... the expression of TET1. At the same time, TET1 of glioma U251 cells was knocked down or overexpressed to observe its effect on glioma cell proliferation and invasion as well as autophagy level. Here, we reported that the expression of TET1 in glioma tissue was significantly lower than the corresponding non...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (5): BSR20171049.
Published: 07 September 2017
... indicated that autophagy also participates in the regulation of cardiac fibrosis. However, the precise role of autophagy in cardiac fibrosis and the underlying molecular mechanism remain unclear. The present study aimed to explore the role of autophagy in EndMT, reveal the underlying molecular mechanism...