...Carlos M. Farinha; Isabelle Callebaut Cystic fibrosis, the most common autosomal recessive disorder in Caucasians, is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene, which encodes a cAMP-activated chloride and bicarbonate channel that regulates ion...

... greater variability for TER values compared with J m . Investigating the dependence of 16HBE TER on transcellular ion conductance, inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel with GlyH-101 produced a large decrease in short-circuit current (I sc...

...Zhengzhang Li; Zhe Shen; Haoping Xue; Shi Cheng; Qun Ji; Yutan Liu; Xiangjun Yang Atherosclerosis is a chronic inflammatory disease of the vascular wall. Dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR) has been shown to result in inflammatory responses in cystic fibrosis...

...Horacio F. Cantiello The cystic fibrosis transmembrane conductance regulator (CFTR) is a member of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. Recent studies indicate that CFTR and other...

...M. A. Gray; J. P. Winpenny; B. Verdon; H. McAlroy; B. E. Argent Cystic fibrosis (CF) affects approximately 1 in 2000 people making it one of the commonest fatal, inherited diseases in the Caucasian population. CF is caused by mutations in a cyclic AMP-regulated chloride channel known as CFTR, which...