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Keywords: CRISPR/Cas9
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Articles
Biosci Rep (2019) 39 (10): BSR20191914.
Published: 15 October 2019
...Hong Pan; Weina Yu; Ming Zhang Precise genome editing with directed base insertion or targeted point mutations can be achieved by CRISPR/Cas9-mediated homology-directed repair (HDR) and is of great significance in clinical disease therapy. However, HDR efficiency, compared with non-homologous end...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20190207.
Published: 21 May 2019
... ) gene can cause the ‘double-muscling’ phenotype. Although there have been many studies performed on MSTN -mutant animals, there have been few studies that have investigated the cystine-knot motif in exon 3 of MSTN in rabbits. In the current study, CRISPR/Cas9 sgRNA anchored exon 3 of a rabbit’s MSTN...
Includes: Supplementary data
Articles
Articles
Biosci Rep (2018) 38 (2): BSR20171490.
Published: 21 March 2018
..., gonad development, or expression of hormones and their receptors during embryonic development during sexual differentiation. SRY is a sex-determination gene on the Y chromosome that is responsible for initiating male sex determination in mammals. In this study, we introduced CRISPR/Cas9-mediated...
Includes: Supplementary data