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Keywords: Cancer
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Articles
Biosci Rep (2024) 44 (9): BSR20231382.
Published: 23 September 2024
...Jackson C. Lin; Ayobami Oludare; Hunmin Jung Purine and pyrimidine nucleotides are crucial building blocks for the survival of cells, and there are layers of pathways to make sure a stable supply of them including de novo nucleotide biosynthesis. Fast-growing cells including cancer cells have high...
Articles
Biosci Rep (2024) 44 (1): BSR20231686.
Published: 09 January 2024
... in the cell walls of fungi, yeasts, bacteria, and cereals. The unique features of β-glucans, such as water solubility, viscosity, molecular weight, and so on, have rendered them to be broadly applied in various food systems as well as in medicine to improve human health. Moreover, inhibition of cancer...
Articles
Biosci Rep (2023) 43 (10): BSR20230489.
Published: 03 October 2023
... distantly placed pathways: amyloid formation and developing cancers in the brain have similarities and are mechanistically intertwined together. Correspondence: Vibhuti Joshi ( [email protected] ) or Arun Upadhyay ( [email protected] ) 14 03 2023 31 05 2023 13...
Articles
Biosci Rep (2023) 43 (10): BSR20222591.
Published: 03 October 2023
... of cancer. The activation of oncogenes is also known to induce severe replication stress. As a result, this hallmark of cancer may provide various promising targets for the development of therapeutic drugs. In this review, we summarize the ubiquitination modifications that regulate DNA replication...
Articles
Biosci Rep (2023) 43 (4): BSR20230627.
Published: 25 April 2023
...Patrick Ball; Emma Thompson; Simon Anderson; Vanessa Gwenin; Amir Ashoorzadeh; Jeff Smaill; Chris Gwenin Directed enzyme prodrug therapy is a highly promising anti-cancer strategy. However, the current technology is limited by inefficient prodrug activation and the dose-limiting toxicity associated...
Includes: Supplementary data
Articles
Biosci Rep (2023) 43 (3): BSR20222174.
Published: 29 March 2023
...Jinyou Yang; Shuyu Xu; Shaozhuo Wang; Xuyan Zou; Mingxiu Duan; Qiaoling Zhang; Chao Wang Gastrointestinal cancers are the most common type of cancer affecting humans. High expression of HOX transcript antisense intergenic RNA (HOTAIR), a long noncoding RNA (lncRNA), in various types of different...
Includes: Supplementary data
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Articles
Biosci Rep (2023) 43 (1): BSR20220489.
Published: 30 January 2023
...-needed therapeutic opportunities to a leukaemia of notoriously poor prognosis. acute myeloid leukaemia cancer chromosomal translocation paediatric Acute myeloid leukaemia (AML) is a genetically heterogeneous clonal malignancy characterised by uncontrolled proliferation and impaired...
Articles
Biosci Rep (2022) 42 (12): BSR20222171.
Published: 22 December 2022
... the bloodstream. Apoptosis inhibition is one of the hallmarks of cancer and its induction in tumors is a widely used therapeutic approach. Apoptosis inhibition and induction correlate with decreased and increased serum levels of cyt c , respectively. The quantification of cyt c in the serum is useful...
Articles
Biosci Rep (2022) 42 (11): BSR20221280.
Published: 21 November 2022
... SET splicing, and cellular localization to cancer progression and development of neurodegenerative tauopathies such as Alzheimer’s disease. Molecular biology tools, such as targeted genetic deletion, and pharmacological approaches based on SET antagonist peptides, have contributed to unveil...
Articles
Biosci Rep (2022) 42 (7): BSR20212051.
Published: 08 July 2022
... materials are widely used as molecular transporter for delivering therapeutics and imaging agents. Nanomedicine involving multi-component chemotherapeutic drug-based combination therapy has been found to be an improved promising approach to increase the efficacy of cancer treatment. Next-generation...
Articles
Articles
Biosci Rep (2022) 42 (4): BSR20211812.
Published: 19 April 2022
...Swagata Adhikari; Apoorva Bhattacharya; Santanu Adhikary; Vipin Singh; Shrikanth S. Gadad; Siddhartha Roy; Chandrima Das Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for the successful management of cancer for decades. In patients...
Articles
Biosci Rep (2022) 42 (2): BSR20211248.
Published: 25 February 2022
... in these cellular locations have not been studied in detail yet. In recent years, MMRN1 has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker. Some evidence suggest that MMRN1 expression is regulated by methylation, protein...
Articles
Biosci Rep (2022) 42 (2): BSR20212721.
Published: 11 February 2022
... and immunoproteasome inhibitor, capable of inducing cell death in multiple myeloma, triple-negative breast cancer, (TNBC) and non-small cell lung cancer lines. TIR-199 also effectively inhibits the proteasome in primary myeloma cells of patients, and bypasses the PSMB5 A49T+A50V bortezomib-resistant mutant. TIR-199...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (2): BSR20212002.
Published: 04 February 2022
... this extraordinary feat through their unique kinetic parameters, myriad regulatory strategies, and their sensitivity to their surroundings, including substrate concentration and pH. The Cancer Genome Atlas (TCGA) highlights the extraordinary number of ways in which the finely tuned activities of enzymes can...
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Articles
Biosci Rep (2021) 41 (12): BSR20211577.
Published: 17 December 2021
... tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate. apoptosis Cancer cell survival metastasis ribosomal proteins Ribosomes...
Articles
Biosci Rep (2021) 41 (11): BSR20211994.
Published: 12 November 2021
... tyrosine phosphorylation has been linked to various diseases, including metabolic disorders and cancer. Few years ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors, able to block the signals emanating from receptor tyrosine kinases. However, recent evidence demonstrates...
Articles
Biosci Rep (2021) 41 (9): BSR20203978.
Published: 17 September 2021
... the expression of RDM1 and expression of marker genes related to immune infiltration. Immunohistochemistry (IHC) method was used to detect the expression level of RDM1 in 90 cases of hepatocellular carcinoma and adjacent normal liver tissues. Results : RDM1 expression was up-regulated in most cancers...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (8): BSR20181627.
Published: 12 August 2021
...Wei Liu; Qin-Peng Wang; Jia Guo Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (6): BSR20210462.
Published: 04 June 2021
.... In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer...
Articles
Biosci Rep (2021) 41 (2): BSR20204043.
Published: 26 February 2021
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer meta-analysis miR-142 prognosis Globally, tumors have become a major disease threatening people’s health. Although great progress has been made...
Articles
Biosci Rep (2021) 41 (2): BSR20193877.
Published: 03 February 2021
... of cancer. Materials and methods: The data used in this research were collected from Google Scholar, Web of Science, CNKI, and Wan Fang Data databases. The final retrieval ended on 22 February 2019. The strength of correlation was assessed using odds ratios and 95% confidence intervals. Based...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203995.
Published: 14 January 2021
...Weiwei Chen; Yuting Li; Liliangzi Guo; Chenxing Zhang; Shaohui Tang Background: Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203559.
Published: 07 January 2021
...Mengqiu Xiong; Ping Wang; Bei Pan; Junjie Nie; Shukui Wang; Bangshun He MicroRNA-196a (miR-196a) was previously reported to be up-regulated in cancers, and it has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203459.
Published: 07 January 2021
...Xiao-Jing Qin; Xu Lin; Gang Xue; Hui-Li Fan; Hao-Yu Wang; Jing-Fang Wu; Da Pei Background: In recent years, the annual incidence of thyroid cancer (TC) has increased, with papillary thyroid cancer (PTC) identified as the most commonwinwordpathological type accounting for approximately 80% of all...
Articles
Biosci Rep (2020) 40 (11): BSR20201820.
Published: 17 November 2020
...Bo Ma; Hui Li; Jia Qiao; Tao Meng; Riyue Yu Background: Head and neck squamous cell carcinoma (HNSCC) is recognised as an immune active cancer, but little is known about the role of microRNAs (miRNAs) in it. In the present study, we aim to determine a prognostic and immune-related miRNAs signature...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20202962.
Published: 13 November 2020
...Zhiding Wang; Mengzhen Wang; Jinghong Chen; Linlin Zhang; Li Zhang; Li Yu Cancer immunotherapy has recently undergone rapid development into a validated therapy for clinical use. The adoptive transfer of engineered autologous T cells, such as chimeric antigen receptor (CAR) T cells, has been...
Articles
Biosci Rep (2020) 40 (10): BSR20192051.
Published: 23 October 2020
...Abdolkarim Moazeni-Roodi; Sahel Sarabandi; Shima Karami; Mohammad Hashemi; Saeid Ghavami Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development...
Articles
Biosci Rep (2020) 40 (9): BSR20202520.
Published: 02 September 2020
...Xiaoqi Yang; Haoran Liu; Tao Ye; Zhangqun Ye Background: Previously published studies have indicated that lymphoid enhancer-binding factor 1 (LEF1) expression could be recognized as a valuable biomarker to evaluate clinical outcome for various types of malignant cancer, but the results remained...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20194468.
Published: 17 July 2020
...Shi Xu Fang; Cheng Chen; Qiang Guo; Xi Xian Ke; Hong Ling Lu; Gang Xu Background: SNHG15 has been reported to be aberrantly expressed in various tumor tissues and could serve as a promising prognostic cancer biomarker. Previous studies on SNHG15 yielded inconsistent results with insufficient...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20191825.
Published: 09 July 2020
...Guang-Hui Qi; Chun-Hui Wang; Hong-Ge Zhang; Jian-Guo Yu; Fei Ding; Zhi-Chao Song; Qing-Hua Xia There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20192410.
Published: 26 June 2020
...Li-Fang Wu; Gui-Ping Xu; Qing Zhao; Ding Wang; Li-Jing Zhou; Bin Sun; Wei-Xian Chen Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions. Methods...
Includes: Supplementary data
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Biosci Rep (2020) 40 (6): BSR20200970.
Published: 08 June 2020
...Zohreh S. Miripour; Parisa Aghaee; Fereshteh Abbasvandi; Parisa Hoseinpour; Mohammad Parniani; Mohammad Abdolahad Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (5): BSR20192320.
Published: 28 May 2020
...Jingdong Li; Yaxuan Wang; Xueliang Chang; Zhenwei Han Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α ( LTA ) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible...
Includes: Supplementary data
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Biosci Rep (2020) 40 (2): BSR20194335.
Published: 28 February 2020
...Dan-dan Hu; Hai-ling Chen; Li-ming Lou; Hong Zhang; Guo-liang Yang The processes that lead to lung adenocarcinoma (LUAD) metastasis are poorly characterized. Spindle and kinetochore associated complex subunit 3 (SKA3) plays a key role in cervical cancer development, but its contribution to LUAD...
Articles
Biosci Rep (2020) 40 (2): BSR20193524.
Published: 07 February 2020
...Yuqin Yu; Dapeng Li; Ji’an Duan; Hongshuang Xu; Li Li; Dengwu Tan; Hong Yan Background: Oxycodone is an opioid medication used for the treatment of pain in cancer patients. However, little is known on the direct effects of oxycodone on cancer cells. Aim: To determine the effects and mechanisms...
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Articles
Biosci Rep (2019) 39 (12): BSR20192452.
Published: 04 December 2019
... of clinical cancer. Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P -value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated. Results We selected a total of 71 eligible...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (10): BSR20192274.
Published: 18 October 2019
...Caizhi Chen; Long Shu; Wen Zou Cancer incidence rate has increased so much that it is the second leading cause of deaths worldwide after cardiovascular diseases. Sensitive and specific biomarkers are needed for an early diagnosis of cancer and in-time treatment. Recent studies have found that long...
Articles
Biosci Rep (2019) 39 (10): BSR20190608.
Published: 11 October 2019
...Jing Ye; Haiyan Sun; Zhengquan Feng; Qiqin Zhang; Yongliang Xia; Yunxi Ji; Qiqing Zhang Background: Dysregulated expression of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA GHET1) has been observed in several cancers, however, definite conclusion on the prognostic value...
Articles
Biosci Rep (2019) 39 (9): BSR20190989.
Published: 20 September 2019
... malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (8): BSR20190590.
Published: 28 August 2019
...Jiamin Zhu; Shusen Chen; Baixia Yang; Weidong Mao; Xi Yang; Jing Cai Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent...
Articles
Biosci Rep (2019) 39 (8): BSR20190741.
Published: 23 August 2019
... rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z -test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (6): BSR20182240.
Published: 28 June 2019
... of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (6): BSR20191298.
Published: 28 June 2019
...Xiaoxia He; Peng Wang; Ying Li; Na Shen Rs189037 (G>A) is an important functional variant with ataxia telangiectasia mutated ( ATM ) gene, which might affect ATM ’s expression involvement in several human cancers. Increasing evidence reveals that smoking-related cancers have distinct molecular...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20190754.
Published: 31 May 2019
..., and is the most common childhood intraocular cancer accounting for 3% of all pediatric cancers [ 1 , 2 ]. The incidence of retinoblastoma is about 1 case in every 15000–20000 live births [ 3 ]. Although the survival rate of retinoblastoma patients is up to 95% in developed countries, the survival rate of patients...
Articles
Biosci Rep (2019) 39 (5): BSR20181785.
Published: 24 May 2019
... (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May...
Articles
Biosci Rep (2019) 39 (5): BSR20190456.
Published: 14 May 2019
...Songsong Teng; Chunhui Ma; Yinxian Yu; Chengqing Yi Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate the expression pattern of TET proteins in these cells. The expression of TET1 was increased...
Includes: Supplementary data