... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer DNA repair missense mutations molecular dynamics simulations NMR spectroscopy tumor suppressor gene Double-strand DNA breaks (DSBs) are severe lesions that introduce discontinuity...

... into the cellular stresses and protective mechanisms that promote seed survival, with a focus on the roles of DNA repair and response mechanisms. Collectively, these pathways function to maintain the germination potential of seeds. Understanding the molecular basis of seed longevity provides important new genetic...

...Chuan Liang; Ye Yang; Ping Ning; Chenyan Chang; Weiguo Cao Enzymes in uracil-DNA glycosylase (UDG) superfamily are involved in removal of deaminated nucleobases such as uracil, methylcytosine derivatives such as formylcytosine and carboxylcytosine, and other base damage in DNA repair. UDGX...

... capacity of the tumour cells. It is known that DNA damage complexity increases with LET that leads to enhanced biological effectiveness, although the specific DNA repair pathways that are activated following the different radiation sources is unclear. This knowledge is required to determine whether...

...Andrew Cubbon; Ivana Ivancic-Bace; Edward L. Bolt Co-opting of CRISPR-Cas ‘Interference’ reactions for editing the genomes of eukaryotic and prokaryotic cells has highlighted crucial support roles for DNA repair systems that strive to maintain genome stability. As front-runners in genome editing...

...Zhi-Qin Liu; Guan-Ge Chen; Ru-Liang Sun; Chao Chen; Mei-Yin Lu; Lan-Fang Guan; Xiao-Ling Chi; You-Qiang Jian; Xiu Zhu; Rui-Qi Liu; Bo-Yu Cai; Fang-Fang Chen; Bin Liu XPG gene contributes to DNA repair defects and genomic instability, which may lead to the initiation of uterine leiomyoma. We...

... by mutation of two amino acid motifs, which also abolished MMC R . RpmG is frequently annotated as a bacterial ribosomal protein, although forms an operon with MutM glycosylase and a putative deubiquitinating (DUB) enzyme, YicR. RpmG associated MMC R was dependent on MutM. MMC R from RpmG resembles DNA repair...

... 21 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Aquifex aeolicus DNA repair endonuclease mismatch repair MutL thermostability DNA MMR (mismatch repair) is a well-conserved DNA repair system and corrects mismatched base pairs produced through...

...-induced apoptosis through the caspase-3 pathway,there was no consistent difference in the activation of this and relatedcaspase-9 caspases compared to parental HeLa cells. © 2000 Plenum Publishing Corporation 2000 Apoptosis DNA repair UV-resistance HeLa Bioscience Reports, Vol. 20, No. 2...