... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Dexmedetomidine EX527 mTOR Myocardial ischemia/reperfusion SIRT1...

...Hui-xian Li; Tai-hang Wang; Lin-xin Wu; Fu-shan Xue; Guo-hua Zhang; Tao Yan Objective: To explore the role and mechanism of the Kelch sample related protein-1-nuclear factor erythroid-2 related factor 2/antioxidant response element (Keap1-Nrf2/ARE) signaling pathway in protection of dexmedetomidine...

... Dexmedetomidine EX527 mTOR Myocardial ischemia/reperfusion SIRT1 The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an Expression of Concern to notify readers whilst the Editorial Office investigates...

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Acute liver injury Dexmedetomidine Lipopolysaccharide This article...

...Fei Tong; Wenchao Shen; Pengtao Song; Jiafeng Song; Yonghe Hu; Feifan Liu; Zhipeng Meng; Jing Liu Objective: The aim of the present study is to investigate the anti-injury and anti-inflammatory effects of dexmedetomidine (Dex) in acute liver injury induced by lipopolysaccharide (LPS) in Sprague...

... toxicities on neural cells may lead to the development of new and safe pharmacotherapy. Dexmedetomidine (DEX), a highly selective α2-adrenoceptor agonist, is a clinically used sedative also known to have neural protection effect. In the present study, we aimed to investigate the protective role of DEX...

...Xiong Zhang; Yongxing Li; Yong Wang; Yuerong Zhuang; Xiaojie Ren; Kai Yang; Wuhua Ma; Ming Zhong Myocardial ischemia/reperfusion (MI/R) triggers a complicated chain of inflammatory reactions. Dexmedetomidine (Dex) has been reported to be important in myocardial disorders. We evaluated the role...

... of dexmedetomidine (DEX) added to sufentanil in intravenous patient-controlled analgesia (PCA) on the relief of pain and inflammatory responses during postoperative recovery of patients undergoing a combined thoracoscopic-laparoscopic esophagectomy (TLE). Methods: Sixty patients undergoing TLE were randomly...

...Peibin Liu; Tufeng Chen; Fang Tan; Jingling Tian; Lei Zheng; Yingqing Deng; Jiaxin Chen; Xinjin Chi Neuropathic pain is a kind of chronic pain that is triggered or caused primarily by damage to the nervous system and neurological dysfunction. It’s known that dexmedetomidine is a new type of highly...

...Lin Zhou; Jinhua Zhou; Bin Sheng; Xin Li; Youchao Yuan Dexmedetomidine (Dex) is an anesthetic widely used in lumbar discectomy, but its effect on chondrocytes remains unclear. Dex is speculated to promote cartilage degeneration by activating α-2 adrenergic receptor. However, the antioxidative...

...Qing-lin Zhang; Lei Wang; Ming-jun Xu; Tian-long Wang The present study aimed to elucidate the effects of dexmedetomidine on kidney injury of parturients with preeclampsia (PE) undergoing cesarean section. Total 134 cesarean delivery women with PE were randomly divided into intervention group (IG...

...Gaofeng Yu; Shangyi Jin; Jinghui Chen; Weifeng Yao; Xingrong Song Objective: Meperidine used to control shivering during perioperative period has associated side effects. The present study compared the safety of selective α2-adrenoreceptor agonist dexmedetomidine and meperidine for anti-shivering...

...). Dexmedetomidine (Dex) is a highly selective α-2 adrenergic receptor agonist that inhibits the activation of NLRP3. Thus, it was hypothesized that Dex could attenuate TBI by inhibiting NLRP3 inflammasome activity in hippocampus. Rats were subjected to controlled cortical impact method to induce TBI, and treated...