... cardiotoxicity doxorubicin mitochondrial dysfunction Nrf2/HO-1 signaling punicalagin The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper “Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through...

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cardiotoxicity doxorubicin long non-coding RNA SNHG1 niR-195...

... patients. However, the underlying mechanisms remain unclear. The purpose of the present study was to evaluate whether sublethal hyperthermia encountered in the periablation zone during thermal ablation enhances the anticancer activity of doxorubicin in chronically hypoxic (encountered in the tumor area...

...Sisi Chen; Jichun Wang; Yanli Zhou Doxorubicin (DOX) is a highly effective anti-tumor drug, but its cardiotoxicity largely restricts its clinical application. The present study was designed to explore whether in vitro DOX toxicity in AC16 cardiomyocytes can be regulated by long non-coding RNA...

...Hong Dai; Ling-yun Xu; Qi Qian; Qiu-wei Zhu; Wei-xian Chen Resistance to doxorubicin (DOX) is the most common clinical problem in breast cancer therapy, and the underlying molecular mechanism remains to be investigated. MicroRNAs (miRNAs) exhibit important regulatory functions in various malignant...

...Mingfang Ye; Linlin Zhang; Yuanming Yan; Huizhong Lin Doxorubicin (DOX) is a wide-spectrum antitumor agent, but its clinical application is largely limited by its cardiotoxicity. Therefore, identification of effective agents against DOX-induced cardiotoxicity is of critical importance. The present...

...R Fabbri; M Macciocca; R Vicenti; G Caprara; MP Piccinni; R Paradisi; P Terzano; A Papi; R Seracchioli Chemotherapy protocol can destroy the reproductive potential of young cancer patients. Doxorubicin (DOX) is a potent anthracycline commonly used in the treatment of numerous malignancies...

...Lijuan Guo; Pengfei Zheng; Huijun Fan; Haiyan Wang; Wenzhong Xu; Wenyan Zhou Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles...

...Frits A. de Wolf The binding of doxorubicin to large unilamellar vesicles consisting of cardiolipin or other anionic phospholipids was analyzed in terms of the local drug concentration at the membrane surface, according to the Gouy-Chapman theory. The analysis suggests strong positive binding...

...Kjell Grankvist; Roger Henriksson To ascertain any differences in myocardial injury exerted by the anthracyclines doxorubicin and epirubicin, their ability to generate oxygen free radicals when mixed with Fe(II) was examined in vitro using an oxygen electrode. 5–250 μg/ml doxorubicin or epirubicin...