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Keywords: EMT
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Articles
Retraction: miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion
Open Access
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (11): BSR-2021-0318_RET.
Published: 11 November 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell invasion cell migration EMT miRNA-103 TBXT This article “miR...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (11): BSR-2019-2645_EOC.
Published: 06 November 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . asthma EMT miR-203a-3p SIX1 Smad3 TGF-β1 The Editorial Office has...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (10): BSR-2020-0199_RET.
Published: 07 October 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT LSZ miR-211 SK-OV-3 This article “Ligustrazine inhibits...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (7): BSR-2018-1339_COR.
Published: 31 July 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cervical Cancer EMT Long non-coding RNA metastasis SPRY4-IT1...
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (5): BSR-2018-0532_RET.
Published: 23 May 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT interleukin 6 JunB STAT3 uveal melanoma This article is being...
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (5): BSR-2019-3169_EOC.
Published: 23 May 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT JAK2/STAT3 signaling Lung adenocarcinoma STEAP1 The Editorial...
Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (1): BSR-2018-0906_RET.
Published: 30 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle EMT FEZF1-AS1 nasopharyngeal carcinoma Wnt/β-catenin signaling...
Articles
Overexpression of RAB34 associates with tumor aggressiveness and immune infiltration in glioma
Open Access
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (10): BSR20212624.
Published: 28 October 2022
... of RAB34 restrained the growth, migration, as well as invasion of glioma cells, and reversed the epithelial-to-mesenchymal transition (EMT) process. Our findings established RAB34 as a novel progression-related biomarker and a possible immunotherapy target for glioma. The TCGA cohort was abstracted...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (3): BSR-20193176_EOC.
Published: 17 March 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA-217 PTPN14 gastric cancer EMT This update follows...
Articles
Jiahui Wei, Yiran Lu, Ruiqing Wang, Xiangzhu Xu, Qing Liu, Song He, Huihao Pan, Xinmiao Liu, Bao Yuan, Yu Ding, Jiabao Zhang
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (9): BSR20211494.
Published: 22 September 2021
... affects the epithelial–mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) and signaling pathways (Wnt signaling pathway, nuclear factor κB (NF-κB) pathway and transforming growth factor β (TGF-β...
Articles
miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion
Open AccessQin Ye, Xing Wang, Mei Yuan, Shuaishuai Cui, Yuanyuan Chen, Zhaodi Hu, Dandan Liu, Conghui Han, Bibo Li, Dahu Chen
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20210318.
Published: 12 August 2021
...-219-5p negatively regulated the expression of TBXT, a known epithelial–mesenchymal transition (EMT) inducer, by directly binding to TBXT 3′-untranslated region. As a result of its inhibition on TBXT expression, miR-219-5p suppressed EMT and cell migration and invasion in breast cancer cells. The re...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20190724_EOC.
Published: 07 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer EMT lncRNA The Editorial Office has been made aware...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20180562_RET.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bladder cancer EMT lncRNA LINC01605 Migration MMP9 This Retraction...
Articles
Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211
Open Access
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20200199.
Published: 05 January 2021
.... The scratch assay was employed to assess cell migration and transwell assay was performed for evaluating the cell invasion. Protein levels of epithelial–mesenchymal transition (EMT) markers were determined by Western blotting. We found that LSZ inhibited the viability, proliferation, migration and invasion...
Articles
Ionizing radiation induces epithelial–mesenchymal transition in human bronchial epithelial cells
Open Access
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20200453.
Published: 07 August 2020
...Bo Tang; Yue Xi; Fengmei Cui; Jin Gao; Huiqin Chen; Wentao Yu; Yu Tu Objective: The present study aimed to analyze the mechanism by which long-term occupational exposure of workers to low-dose ionizing irradiation induces epithelial–mesenchymal transition (EMT) of the human bronchial epithelial...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR-20181476_COR.
Published: 26 June 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . LDH-A LUAD Prognosis Tumor progression EMT The authors...
Articles
Shu-fen Huo, Wen-li Shang, Min Yu, Xiao-ping Ren, Hong-xia Wen, Chun-yan Chai, Li Sun, Ke Hui, Ling-hua Liu, Sheng-hong Wei, Xiao-xiao Wang, Yi Wang, Ying-xuan Tian
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20193169.
Published: 17 June 2020
... proliferation was tested by CCK8 assay. The effects of STEAP1 on the metastasis and epithelial–mesenchymal transition (EMT) of LUAD were evaluated by EdU assay, wound healing assay, and transwell migratory assay. H1650, H358, HCC827, H1299, H23, A549, H1693 were selected as human LUAD cell lines in the study...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR-20180562_COR.
Published: 12 May 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bladder cancer lncRNA LINC01605 EMT MMP9 Migration The authors...
Articles
20(S)-ginsenoside Rh2 as agent for the treatment of LMN-CRC via regulating epithelial–mesenchymal transition
Open Access
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20191507.
Published: 25 March 2020
... metastasis by affecting epithelial–mesenchymal transition (EMT), which significantly up-regulated epithelial biomarkers (E-cadherin) and down-regulated mesenchymal biomarkers (N-cadherin and vimentin) and EMT transcriptional factors (Smad-3, Snail-1, and Twist-1). In vivo , SGRh2 significantly inhibited LMN...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20200164.
Published: 20 March 2020
...Nam Ji Sung; Na Hui Kim; Na Young Bae; Hyo Sik Jo; Sin-Aye Park Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundant in fish oils. It is known to have an inhibitory effect on various diseases such as inflammation, diabetes, and cancer. Epithelial-to-mesenchymal transition (EMT) is a process...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194496.
Published: 04 March 2020
...Ke Wu; Lei Li; Lin Li; Dong Wang Objective: To investigate the specific function of long non-coding RNA HAL in serous ovarian cancer (SOC) and to further clarify the regulation of HAL on EMT pathway. Materials and methods: The expression of HAL and TWIST1 was detected by qRT-PCR. CCK8 assay, wound...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20192645.
Published: 28 February 2020
...) treatment induced the reduction of miR-203a-3p and the enhancement of SIX1 in BEAS-2B and 16HBE cells in a time-dependent manner. Subsequently, functional experiments showed the promotion of epithelial–mesenchymal transition (EMT) induced by TGF-β1 treatment could be reversed by miR-203a-3p re-expression...
Includes: Supplementary data
Articles
Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis
Open AccessChang-Mei Weng, Qing Li, Kui-Jun Chen, Cheng-Xiong Xu, Meng-Sheng Deng, Tao Li, Dong-Dong Zhang, Zhao-Xia Duan, Zhi-Qiang Chen, Guan-Hua Li, Jing Chen, Jian-Min Wang
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20190756.
Published: 14 January 2020
... and pathogenesis remain unclear. Studies have revealed that epithelial–mesenchymal transition (EMT) is a crucial cellular event in IPF. Here, we identified that the pulmonary fibrosis inducer bleomycin simultaneously increased the expression of bFGF and TGF-β1 and inhibited epithelial-specific regulatory protein...
Articles
microRNA-217 suppressed epithelial-to-mesenchymal transition through targeting PTPN14 in gastric cancer
Open Access
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20193176.
Published: 07 January 2020
...) on gastric cell lines. Epithelial-to-mesenchymal transition (EMT) markers were assayed by Western blot. Results: We found that miR-217 had a low level expression in gastric tumor tissues of 40 patients with GC, and a lower expression in the gastric tumor tissues of the patients with GC metastasis. Moreover...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20191237.
Published: 23 August 2019
... non-OS specimens by real-time PCR and western blot. Then, viability, invasion, and epithelial mesenchymal transition (EMT) of OS cell lines were examined when overexpressed or knocked down miR-93, or overexpressed TIMP2. Finally, the interaction between miR-93 and TIMP2 was evaluated using mutation...
Articles
Long noncoding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-κB signaling pathway
Open Access
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190724.
Published: 05 July 2019
... the cell proliferation, cell survival rates, and invaded cells. We also provided evidence that FAM3D-AS1 reversed the EMT process. Moreover, we proved that FAM3D-AS1 inhibits CRC development through NF-κB signaling pathway. Taken together, we performed functional analysis of FAM3D-AS1 and provided...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20181339.
Published: 04 June 2019
...-IT1 significantly suppressed the epithelial–mesenchymal transition (EMT) of CC by increased E-cadherin expression and decreased the N-cadherin and vimentin expression. Mechanically, SPRY4-IT1 could directly bind to miR-101-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-101-3p...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181457.
Published: 31 May 2019
..., proliferation and induce the apoptosis of HCC cell line. Meanwhile, inhibition of DUXAP10 attenuates the cell migration, invasion, and epithelial–mesenchymal transition (EMT) process. No significant change of JNK MAPK pathway was detected in DUXAP10 siRNA transfected HCC cell lines. The β-catenin and pAkt...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (3): BSR20180879.
Published: 01 March 2019
... in cell activity, proliferation and invasive ability. Further study showed that miR-218-5p transfection could inhibit epithelial–mesenchymal transitions (EMT). Therefore, miR-218-5p targeting LHFPL3 mRNA plays significant roles in preventing the invasiveness of glioma cells. The present study also...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20181476.
Published: 15 January 2019
... progression by regulating epithelial–mesenchymal transition (EMT)-related molecules. LDH-A can promote the malignant biological behaviors of LUAD cells, and thus can be a potential target for LUAD treatment. Lung cancer is a malignant tumor with the highest morbidity and mortality worldwide. Among all...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20180906.
Published: 08 January 2019
... knockdown. Moreover, we demonstrated that inhibition of FEZF1-AS1 remarkably suppressed epithelial–mesenchymal transition (EMT) and reduced β-catenin accumulation in nucleus in NPC cells. Conclusions: Collectively, we showed that FEZF1-AS1 might be a key regulator of cell cycle, EMT and Wnt/β-catenin...
Articles
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway
Open Access
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181501.
Published: 14 December 2018
..., epithelial–mesenchymal transition (EMT)-related proteins and activity of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling in U2OS and MG-63 cells exposure to MDA19. Overall, the current study indicates in vitro anti-proliferative, anti-metastatic, and pro-apoptotic...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180677.
Published: 02 October 2018
... to this work. 02 05 2018 15 06 2018 02 07 2018 02 07 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EMT...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180566.
Published: 28 September 2018
.... 12 04 2018 26 05 2018 07 06 2018 08 06 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ceRNA EMT...
Articles
Zhiqiang Qin, Yi Wang, Jingyuan Tang, Lei Zhang, Ran Li, Jianxin Xue, Peng Han, Wei Wang, Chao Qin, Qianwei Xing, Jie Yang, Wei Zhang
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180562.
Published: 05 September 2018
... . Mechanistically, LINC01605 could activate epithelial–mesenchymal transition (EMT) signaling pathway and promote the expression of matrix metallopeptidase (MMP) 9 (MMP9). In summary, our results shed light on that LINC01605, as a new prognostic biomarker, could promote the proliferation, migration, and invasion...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180532.
Published: 03 July 2018
.... Moreover, IL-6 treatment decreased the membranous epithelial marker TJP1 and increased the cytoplasmic mesenchymal marker Vimentin. Further investigation demonstrated that JunB played a critical role in IL-6-induced UM epithelial–mesenchymal transition (EMT). In UM cells, the expression of JunB...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (6): BSR20170658.
Published: 09 November 2017
... of fibroblasts. Western blotting assay demonstrated that ozone oil increased the epithelial–mesenchymal transition (EMT) process in fibroblasts via up-regulating fibronectin, vimentin, N-cadherin, MMP-2, MMP-9, insulin-like growth factor binding protein (IGFBP)-3, IGFBP5, and IGFBP6, and decreasing epithelial...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160643.
Published: 27 March 2017
... remain poorly understood. In the present study, we demonstrate that up-regulation of Fra1 plays a crucial role in the glioma aggressiveness and epithelial–mesenchymal transition (EMT) activated by Wnt/β-catenin signal pathway. In glioma cells, activation of Wnt/β-catenin signalling by Wnt3a...
Articles
Suitable parameter choice on quantitative morphology of A549 cell in epithelial–mesenchymal transition
Open Access
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (3): e00202.
Published: 11 June 2015
...Zhou-Xin Ren; Hai-Bin Yu; Jian-Sheng Li; Jun-Ling Shen; Wen-Sen Du Evaluation of morphological changes in cells is an integral part of study on epithelial to mesenchymal transition (EMT), however, only a few papers reported the changes in quantitative parameters and no article compared different...
