... of promoters. These structures comprise the so-called G-quadruplexes (G4s) that are formed from sequences rich in guanine bases. Using a well-defined transcriptional reporter system, we sought to systematically investigate the impact of the presence of G4 structures on transcription in yeast Saccharomyces...

...Jing Yan; Deming Zhao; Liping Dong; Shuang Pan; Fengjin Hao; Yifu Guan It is known that the guanine-rich strands in proto-oncogene promoters can fold into G-quadruplex structures to regulate gene expression. An intramolecular parallel G-quadruplex has been identified in MET promoter. It acts...

...Jing You; Hui Li; Xi-Ming Lu; Wei Li; Peng-Ye Wang; Shuo-Xing Dou; Xu-Guang Xi G-quadruplexes are special structures existing at the ends of human telomeres, the folding kinetics of which are essential for their functions, such as in the maintenance of genome stability and the protection...

...Marek Petr; Robert Helma; Alena Polášková; Aneta Krejčí; Zuzana Dvořáková; Iva Kejnovská; Lucie Navrátilová; Matej Adámik; Michaela Vorlíčková; Marie Brázdová G-quadruplexes are four-stranded nucleic acid structures that are implicated in the regulation of transcription, translation and replication...