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Keywords: Glutamatergic activity
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Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases

Open Access
Shazia Dawood, Samina Bano, Abdulla A.-B. Badawy
Journal: Bioscience Reports
Biosci Rep (2022) 42 (5): BSR20220426.
https://doi.org/10.1042/BSR20220426
Published: 27 May 2022
... kynurenine monooxygenase thereby antagonising glutamatergic activation to normalise serotonin function. Antidepressants with anti-inflammatory properties are unlikely to act by direct inhibition of IDO but may inhibit IDO induction by lowering levels of proinflammatory cytokines in immune-activated patients...
View articletitled, Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases
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Includes: Supplementary data