...Jiyuan Xing; Shen Shen; Xiaorui Liu; Yang Zhang Hypoxia and hypoxia-related genes regulate tumor initiation and progression. However, the exact roles that hypoxia plays in hepatocellular carcinoma (HCC) remain unclear. In the present study, we calculated the hypoxia score of each sample...

...Pengyu Wang; Xitong Yang; Dan Liu; Yunhui Yang; Yuanyuan Zhang; Guangming Wang Hepatocellular carcinoma (HCC) is a common malignant tumour with high rates of morbidity and mortality worldwide. Therefore, it is of great significance to find new molecular markers for HCC diagnosis and treatment. G6PD...

...Xiaohan Zhou; Chengdong Liu; Hanyi Zeng; Dehua Wu; Li Liu Background: Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system characterized by mortality rate and poor prognosis. To indicate the prognosis of HCC patients, lots of genes have been screened as prognostic indicators...

.... The present study provides an initial exploration of the relationship between HBV mutation and integration to help improve our understanding of the relationship between viral integration and mutation. HBV integration HBV HCC SNV TERT Correspondence: Weiyang Li ( [email protected]...

... per million base pair, and MSI was counted by the number of insertion or deletion events that occurred in repeating sequences of genes. HCC ICGC pan-cancer TCGA YIF1B Serotonin, a known neurotransmitter, has recently emerged as a tumor growth factor for several human cancers...

...Jing Feng; Jian Guo; Pengyu Zhao; Jing Shen; Baofeng Chai; Junping Wang Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Recent studies showed that snRNPs were implicated in human cancer development. The role of SNRPA1, which is a member of U2 snRNPs...

...Wei Xuan; Chen Zhou; Guangqiang You Liver cancer is now one of the most lethal and commonest cancers in the world, among which over 90% is hepatocellular carcinoma (HCC). Recent studies have confirmed long non-coding RNAs (lncRNAs) are implicated in carcinogenesis. It has been reported lncRNA...

...Xiao-Song Li; Jun-Wei Li; Hui Li; Tao Jiang The prognostic role of programmed death ligand-1 (PD-L1) expression in hepatocellular carcinoma (HCC) has been widely studied but the results are controversial. In this comprehensive meta-analysis, we elucidated the clinical value of PD-L1 in HCC...

...Qingqing Lu; Jie Li; Hui Cao; Chenlu Lv; Xiaolin Wang; Shiqiong Cao Objective: Midkine (MDK) has been proposed as one of the most promising markers for hepatocellular carcinoma (HCC). This meta-analysis was conducted to compare the diagnostic accuracy of MDK and α-fetoprotein (AFP) for HCC. Methods...

...Liang Xiao; Furong Zeng; Guangtong Deng Some doubts were generated during the reading of nomograms based on inflammatory biomarkers for preoperatively predicting tumor grade and microvascular invasion in stage I/II hepatocellular carcinoma (HCC). We would like to highlight and discuss with authors...

...Wen-Feng Gong; Jian-Hong Zhong; Zhan Lu; Qiu-Ming Zhang; Zhi-Yuan Zhang; Chang-Zhi Chen; Xu Liu; Liang Ma; Zhi-Ming Zhang; Bang-De Xiang; Le-Qun Li Aim: To explore clinical factors associated with extent of liver regeneration after hemihepatectomy to treat hepatocellular carcinoma (HCC). Methods...

...) infection and risk of chronic hepatocellular carcinoma (HCC). Owing to limitation of sample size and inconclusive results, we conducted a meta-analysis to clarify the association. Methods: We identified relevant studies by a systematic search of Medline/PubMed, Embase, Web of Science and the Cochrane...

...Haichuan Wang; Hui Cao; Zhong Xu; Dong Wang; Yong Zeng The association of major histocompatibility complex class I chain-related gene A ( MICA ) single nucleotide polymorphism (SNP) rs2596542G>A and hepatocellular carcinoma (HCC) has been broadly studied, with inconsistent results. Therefore, we...

... in hepatocellular carcinoma (HCC) and explored the relationship between expression of NDRG3 in HCC patients and their clinicopathological characteristics. We performed quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) analysis and immunohistochemistry (IHC) analyses on HCC tissues...

...Bisha Ding; Weiyang Lou; Liang Xu; Weimin Fan Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs...

... carcinoma (HCC) cell lines was conducted. After screening the microarray assay data of ten HCC cell lines, 19 candidate reference genes were preselected and then evaluated by qRT-PCR, together with ACTB, GAPDH, HPRT1 and TUBB . The expression evenness of these candidate genes was evaluated using RefFinder...

... patients with diagnosed hepatocellular carcinoma (HCC) and compared the correlation between the changes of telomere lengths in these defined samples. Patients included had either HCC alone or in conjunction with either pre-existing hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. PCR-based...