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Keyword: Hexokinase 2
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Journal Articles
Bioscience Reports (8 May 2018) 38 (3): BSR20171383.
Published: 08 May 2018
... evidence that glucose uptake, lactate production, and key glycolysis enzymes were elevated in imatinib resistant cells. Importantly, the imatinib resistant CML cell lines were more sensitive to glucose starvation and glycolysis inhibitors. In addition, we identified Hexokinase 2 (HK2) as a direct target of...
Journal Articles
Bioscience Reports (21 February 2018) 38 (1): BSR20171666.
Published: 21 February 2018
...’. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in all aggressive tumors and predominantly found on the outer mitochondrial membrane, where interactions through its N-terminus initiates...
Includes: Supplementary data
Journal Articles
Bioscience Reports (4 July 2017) 37 (4): BSR20170216.
Published: 04 July 2017
...) results showed that miR-143 was significantly induced by ischemia injury. Meanwhile, we observed suppression of glucose uptake and lactate product of rat brain and primary neurones after MCAO or OGD. The glycolysis enzymes hexokinase 2 (HK2), PKM2, and LDHA were inhibited by MCAO or OGD at protein and...
Journal Articles
Bioscience Reports (7 June 2017) 37 (3): BSR20160404.
Published: 07 June 2017
... apoptosis and significantly caused cell cycle arrest at G 1 stage. The colony formation of oral cancer cells was also suppressed by miR-143 . We identified hexokinase 2 (HK2) as a direct target of miR-143 in oral cancer cells. Our data show that miR-143 complementary pairs to the 3′-UTR of HK2 in oral...