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1-36 of 36
Keywords: Hypoxia
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Articles
Rahul Kumar, Neha Chanana, Kavita Sharma, Tsering Palmo, Michael H. Lee, Aastha Mishra, Kevin Nolan, Dara C. Fonseca Balladares, Claudia Mickael, Mohit D. Gupta, Tashi Thinlas, Qadar Pasha, Brian B. Graham
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (11): BSR20231561.
Published: 30 November 2023
...-altitude hypoxia inflammation Peripheral blood mononuclear cells pulmonary hypertension Acute high-altitude (HA) environmental exposure can cause several pathologies, including acute mountain sickness (AMS), pulmonary hypertension (PH), HA pulmonary edema (HAPE), and HA cerebral edema (HACE...
Articles
Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Guo
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (9): BSR20230014.
Published: 05 September 2023
... the effects of miR-21 and homeodomain interacting protein kinase 3 (HIPK3) on cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) in vitro . To this end, the rat cardiomyocyte H9C2 cell line was exposed to H/R and the roles of miR-21 and HIPK3 in regulating cell viability and apoptosis were...
Includes: Supplementary data
Articles
Hisham Al-Ward, Ning Liu, Moussa Omorou, Yiwei Huang, Wei Chen, Chun-Yang Liu, Shaochun Lv, Abduh Murshed, Fahmi Shaher, Yao Li, Yuxuan Zhang, Linxia Lu, Wenxia Gao, Yi Eve Sun, Hui Xu
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (1): BSR20222016.
Published: 16 January 2023
...-ischemic brain injury. We found that after 10 min of hypoxia-ischemia, all reperfusion groups showed different degrees of damage. The degree of the injury increased in all the groups after 30 min of hypoxia-ischemia. Those changes include changes in the pericellular lumen, capillaries in the cortex...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (11): BSR20221089.
Published: 18 November 2022
...Jiyuan Xing; Shen Shen; Xiaorui Liu; Yang Zhang Hypoxia and hypoxia-related genes regulate tumor initiation and progression. However, the exact roles that hypoxia plays in hepatocellular carcinoma (HCC) remain unclear. In the present study, we calculated the hypoxia score of each sample...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (3): BSR20211696.
Published: 23 March 2022
.... cell death hypoxia ischaemia-reperfusion injury mitochondrial dynamics neonatal The cellular energy required by the developing brain around the time of birth and during early life is substantial, emphatically illustrated by the rapid increase from 27 to 80% of its adult weight within...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210764.
Published: 06 July 2021
... expression related with CD8 + T, NK, and TFH cell infiltration. Besides, hypoxia-inducible factor-1α (HIF1A) could increase PTTG3P expression by binding to the PTTG3P promoter region. Hypoxia-induced PTTG3P contributes to glycolysis and M2 phenotype of macrophage, which proposes a novel approach for clinical...
Includes: Supplementary data
Articles
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males
Rob G.H. Driessen, Dorien Kiers, Casper G. Schalkwijk, Jean L.J.M. Scheijen, Jelle Gerretsen, Peter Pickkers, Marcel C.G. van de Poll, Iwan C.C. van der Horst, Dennis C.J.J. Bergmans, Matthijs Kox, Bas C.T. van Bussel
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210954.
Published: 02 July 2021
...Rob G.H. Driessen; Dorien Kiers; Casper G. Schalkwijk; Jean L.J.M. Scheijen; Jelle Gerretsen; Peter Pickkers; Marcel C.G. van de Poll; Iwan C.C. van der Horst; Dennis C.J.J. Bergmans; Matthijs Kox; Bas C.T. van Bussel Background: Hypoxia and inflammation are hallmarks of critical illness, related...
Articles
Qi Wang, Hui Zhang, Qian-qian Ren, Tian-he Ye, Yi-ming Liu, Chuan-sheng Zheng, Guo-feng Zhou, Xiang-wen Xia
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20210442.
Published: 11 June 2021
... inside the ablation zone decreases from the center to the margin, where the temperature is sublethal and residual viable tumor cells often exist, which potential cause tumor relapse [ 16 , 17 ]. In our previous study, we reported that chronic hypoxia, an important characteristic following TACE, triggers...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20203170.
Published: 02 June 2021
... of these in vivo adaptations during sustained hypoxia, the heart up-regulates and maintains a high glycolytic flux, but the underlying mechanism is still elusive. We followed the cardiac glycolytic responses to a chronic hypoxic (CH) intervention using [5- 3 H]-glucose labelling in combination with detailed...
Includes: Supplementary data
Articles
In Collection
Coronavirus
Sarbashri Bank, Subrata Kumar De, Biswabandhu Bankura, Smarajit Maiti, Madhusudan Das, Gausal A Khan
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (2): BSR20202014.
Published: 01 February 2021
... the receptor recognition (begining of infection) and followed by the impact of cytokine and hypoxia in the context of the balance of ACE/ACE2. It has also very concisely delineated the biochemistry and mechanism of ACE/ACE2 balance in different stages of infection and its role in comorbidity. When...
Articles
Xiuru Zhang, Tingting Li, Shuwen Liu, Yiming Xu, Minjun Meng, Xiumin Li, Zhichao Lin, Qici Wu, Yu Xue, Yutian Pan, Gulimiran Alitongbieke
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (12): BSR20201006.
Published: 14 December 2020
...Xiuru Zhang; Tingting Li; Shuwen Liu; Yiming Xu; Minjun Meng; Xiumin Li; Zhichao Lin; Qici Wu; Yu Xue; Yutian Pan; Gulimiran Alitongbieke Background: β-glucan from Lentinus edodes (LNT) is a plant-derived medicinal fungus possessing significant bioactivities on anti-tumor. Both hypoxia-induced...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20194284.
Published: 28 May 2020
... cells cultured in normoxic condition. Hypoxia-induced increased migration and invasion abilities were mitigated by DHE in A549 cells. Treatment of DHE caused increased E-cadherin expression and decreased N-cadherin expression in hypoxia-induced A549 cells. DHE also suppressed hypoxia-induced increase...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20192457.
Published: 31 March 2020
... from chemotherapy resistance. In OC, cancer cells become resistant to paclitaxel chemotherapy under hypoxic environment. The miR-27a has been identified as an oncogenic molecular in ovarian cancer, prostate cancer, liver cancer etc. In addition, the miR-27a is involved in hypoxia-induced...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20194200.
Published: 20 February 2020
...Hongxia Li; Li Tong; Hong Tao; Zhe Liu Lung adenocarcinoma (LUAD) is a common type of lung cancer with high incidence and poor prognosis. Hypoxia and DNA methylation play important regulatory roles in cancer progression. The purpose of the present study was to explore the relationship between...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20192345.
Published: 24 January 2020
...Judy Kim; Ivraym B. Barsoum; Harrison Loh; Jean-François Paré; D. Robert Siemens; Charles H. Graham A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20192101.
Published: 16 September 2019
... of mitochondria revealed that only RelA was found in the mitoplast, the location of the mtDNA. We demonstrate that hypoxia leads to a very rapid but transient accumulation of RelA and IκBα in mitochondria. This effect required reactive oxygen species (ROS) but was not dependent on the hypoxia sensing...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20181783.
Published: 02 April 2019
...Qinshuo Zhao; Dating Sun; Yuanyuan Li; Jin Qin; JiangTao Yan Hypoxia may cause abnormal proliferation and migration of the vascular smooth muscle cells (VSMCs) from the media to the intima. This contributes to vessel narrowing and accelerates the process of atherosclerosis. The association...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20181165.
Published: 08 January 2019
...Wei Li; Yubo Zhou Intratumoral hypoxia is a well-known feature of solid cancers and constitutes a major contributor to cancer metastasis and poor outcomes including melanoma. Leucine-rich repeats and Ig-like domains 1 (LRIG1) participate in the aggressive progression of several tumors, where its...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181389.
Published: 18 December 2018
...Hong Pan; Qiuhong Chen; Shenggui Qi; Tengyan Li; Beihong Liu; Shiming Liu; Xu Ma; Binbin Wang EPAS1 encodes HIF2 and is closely related to high altitude chronic hypoxia. Mutations in the EPAS1 coding sequence are associated with several kinds of human diseases, including syndromic congenital heart...
Articles
Laurent M. Paardekooper, Maura B. Bendix, Andrea Ottria, Lieke W. de Haer, Martin ter Beest, Timothy R.D.J. Radstake, Wioleta Marut, Geert van den Bogaart
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20182019.
Published: 14 December 2018
... during the respiratory burst. DCs respond to oxygen levels to tailor immune responses to such low-oxygen environments. In the present study, we identified a mechanism of hypoxia-mediated potentiation of release of tumor necrosis factor α (TNF-α), a pro-inflammatory cytokine with important roles in both...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180185.
Published: 29 August 2018
...Yousef K. Al-Mutawa; Anne Herrmann; Catriona Corbishley; Paul D. Losty; Marie Phelan; Violaine Sée Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we...
Includes: Supplementary data
Articles
Xiaolong Zhang, Linhua Lan, Lili Niu, Juping Lu, Changxi Li, Miaomiao Guo, Shouyong Mo, Jing Lu, Yongzhang Liu, Bin Lu
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (6): BSR20171006.
Published: 12 December 2017
... further found that TE-1 cells treated with CoCl 2 , a hypoxia-mimicking reagent, dramatically reduced the oxygen consumption rate (OCR) and increased the extracellular acidification rate (ECAR). However, H 2 O 2 treatment decreased both the mitochondrial respiration and aerobic glycolysis significantly...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (6): BSR20170195.
Published: 29 November 2017
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . erythropoiesis erythropoietin hypoxia hepcidin iron metabolism transferrin receptors Red blood cells (RBCs) perform one of the most vital functions in the human body; the transport of oxygen...
Articles
Jin Zou, Yanhua Liu, Bingong Li, Zeqi Zheng, Xuan Ke, Yanqin Hao, Xuelian Li, Xingxing Li, Fuyou Liu, Zhiyong Zhang
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (5): BSR20171049.
Published: 07 September 2017
..., and seek new therapy for cardiac fibrosis. In the present study, we found that EndMT and autophagy were induced simultaneously by hypoxia in human cardiac microvascular endothelial cells (HCMECs). Rapamycin, an autophagy enhancer, attenuated EndMT with promoting angiogenesis, while 3-methyladenine (3-MA...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (4): BSR20170763.
Published: 27 July 2017
... selective blocker of calcium-activated potassium channel 3.1 (Kca3.1), can help prevent such hypertension by reducing proliferation in PASMCs. Rats were exposed to hypoxia (10% O 2 ) for 3 weeks and treated daily with TRAM-34 intraperitoneally from the first day of hypoxia. Animals were killed and examined...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (4): BSR20170707.
Published: 07 July 2017
.... There was significant relocalization of eIF4A3 and Mago from the nucleus to cytoplasm following 18 h of hypoxia. Treating myocytes with 50 mM NaN 3 for 4 h to mimic the metabolic stress induced by hypoxia also resulted in significant relocalization of eIF4A3 and Mago to the cytoplasm. To examine whether the effects...
Includes: Multimedia, Supplementary data
Articles
Isabelle Tcholakov, Charles E. Grimshaw, Lihong Shi, Andre Kiryanov, Sean T. Murphy, Christopher J. Larson, Artur Plonowski, Jacques Ermolieff
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (3): BSR20170275.
Published: 30 June 2017
...Isabelle Tcholakov; Charles E. Grimshaw; Lihong Shi; Andre Kiryanov; Sean T. Murphy; Christopher J. Larson; Artur Plonowski; Jacques Ermolieff Prolyl hydroxylases (PHDs) down-regulate the level of hypoxia-inducible factors (HIFs) by hydroxylating key proline residues that trigger the degradation...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160622.
Published: 20 April 2017
...Kai Zhang; Dianming Jiang Chondrocytes that are embedded within the growth plate or the intervertebral disc are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signalling pathways underlining the hypoxia-induced mitochondrial...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (1): BSR20160479.
Published: 03 February 2017
...Geng Yin; Yan Liang; Ying Wang; Yuan Yang; Min Yang; Xiao-min Cen; Qi-bing Xie Mammalian cells adapt to different environmental conditions and alter cellular metabolic pathways to meet the energy demand for survival. Thus, the metabolic regulation of cells under special conditions, such as hypoxia...
Articles
Journal:
Bioscience Reports
Biosci Rep (2016) 36 (3): e00345.
Published: 17 June 2016
... to promote autophagy in ischaemic/hypoxic (I/R) heart. However, it's far more to clarify the orchestrated cross-talk between AMPK and other signalling pathways in the autophagy. In the present study, we investigated the autophagy induction by hypoxia in Rat H9C2 cardiomyocytes with LC3-EGFP reporter, EM...
Articles
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (3): e00192.
Published: 19 May 2015
..., thus limiting the amount of iron released into the blood. The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis. The present review summarizes our present knowledge about the molecular mechanisms and signalling pathways contributing...
Articles
Journal:
Bioscience Reports
Biosci Rep (2014) 34 (4): e00127.
Published: 29 July 2014
...Daniel Bandarra; John Biddlestone; Sharon Mudie; H. Arno Muller; Sonia Rocha Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen...
Articles
Nívea Dias Amoêdo, Juan Perez Valencia, Mariana Figueiredo Rodrigues, Antonio Galina, Franklin David Rumjanek
Journal:
Bioscience Reports
Biosci Rep (2013) 33 (6): e00080.
Published: 15 November 2013
... coined as oncometabolites [ 6 ]. Thus, beginning with glucose transporters and proceeding along the pathway one could discriminate which members are up-regulated at the level of transcription. Hypoxia promotes the stabilization of HIF (hypoxia-inducible factor) 1 and 2, that in turn activate...
Articles
Ahlam A. Ali, Jonathan A. Coulter, Claire H. Ogle, Marie M. Migaud, David G. Hirst, Tracy Robson, Helen O. McCarthy
Journal:
Bioscience Reports
Biosci Rep (2013) 33 (2): e00031.
Published: 28 March 2013
... investigations revealed that neither ONOO − (peroxynitrite) nor nitroxyl was generated. Fluorimetric analysis in the presence of scavengers suggest for the first time that another RNS, dinitrogen trioxide may be responsible for the cytotoxicity with DETA/NO. Results showed destabilization of HIF (hypoxia...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2011) 31 (5): 439–447.
Published: 05 August 2011
... constituent from G. biloba , bilobalide, was screened for protective effects on the ischaemic heart and the involvement of the PAFR [PAF (platelet-activating factor) receptor] and the enzyme that degrades PAF, PAF-AH (PAF acetylhydrolase) during hypoxia. The PAF pathway is supposed to play a role in hypoxia...
Articles
Journal:
Bioscience Reports
Biosci Rep (1999) 19 (2): 99–107.
Published: 01 April 1999
...Oscar K. Serrano; Aleksandar Jovanovic; Andre Terzic Although tight regulation of intracellular pH (pHi) is critical for the survival under stress, paradoxically a slowed recovery of pHi under hypoxic injury may be cardioprotective. In this study, we investigated the recovery of pHi after hypoxia...
