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Correction: The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens

Biosci Rep (2025) 45 (03): 213.

https://doi.org/10.1042/BSR20194296_COR

Published: 31 March 2025

... © 2025 The Author(s). 2025 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene expression gold nanoparticles histopathology inflammation...

View articletitled, Correction: The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens

Articles

The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension

Jitesh Singh Rathee, Dhanya R. Iyer, Malapaka Kiranmayi, Samarasimha Reddy, V.V. Sureshbabu, Nitish R. Mahapatra

Biosci Rep (2024) 44 (12): BSR20241433.

https://doi.org/10.1042/BSR20241433

Published: 12 December 2024

... BY) . blood pressure cardioprotection catestatin human genetic variant inflammation Department of Atomic Energy, Government of India (DAE) 501100001502 Department of Biotechnology, Ministry of Science and Technology, India (DBT) 501100001407 BT/PR12820/BRB/10/726/2009 Department...

View articletitled, The physiological anti-hypertensive peptide catestatin and its common human variant Gly364Ser: differential cardiovascular effects in a rat model of hypertension

Includes: Supplementary data

Articles

Correction: Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress, and cell death in mice kidney

Biosci Rep (2024) 44 (10): BSR-2023-1130_COR.

https://doi.org/10.1042/BSR-2023-1130_COR

Published: 29 October 2024

... cisplatin inflammation selenium nanoparticles turmeric extract The authors of the original article “Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney” ( 10.1042/BSR20231130...

View articletitled, Correction: Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress, and cell death in mice kidney

Articles

Retraction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Biosci Rep (2024) 44 (10): BSR-2019-3431_RET.

https://doi.org/10.1042/BSR-2019-3431_RET

Published: 07 October 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Endothelial cells Hippo-YAP Pathway inflammation Naringin...

View articletitled, Retraction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Articles

Editorial Note: Bioactive lipids in intervertebral disc (IVD) degeneration and its therapeutic implications

Biosci Rep (2024) 44 (8): BSR-2019-2117_EDN.

https://doi.org/10.1042/BSR-2019-2117_EDN

Published: 28 August 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . degeneration eicosanoids inflammation intervertebral disc lipoxin A4...

View articletitled, Editorial Note: Bioactive lipids in intervertebral disc (IVD) degeneration and its therapeutic implications

Articles

Bioactivity, hemocompatibility, and inflammatory response of calcium incorporated sulfonated polyether ether ketone on mouse-derived bone marrow cells

Shanmuga Sundar Saravanabhavan, Prabhu Narayanaswamy Venkatesan, Narendranath Jonna, Kamalakannan Vasantha Palaniappan, Zsolt Sarang, Balasubramanian Natesan, Consolato M. Sergi

Biosci Rep (2024) 44 (6): BSR20232162.

https://doi.org/10.1042/BSR20232162

Published: 26 June 2024

... and sulfonated polyether ether ketone (Ca-SPEEK) that can function as a successful biomaterial without causing inflammation when tested on bone marrow cells. The Ca-SPEEK exhibited 13 ± 0.5% clot with low fibrin mesh formation compared to 21 ± 0.5% in SPEEK. In addition, the Ca-SPEEK showed higher protein...

View articletitled, Bioactivity, hemocompatibility, and inflammatory response of calcium incorporated sulfonated polyether ether ketone on mouse-derived bone marrow cells

Includes: Supplementary data

Articles

GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes

Caifeng Chen, Renhui Cai, Jun Zhou, Danqun Zhang, Li Chen

Biosci Rep (2024) 44 (6): BSR20231347.

https://doi.org/10.1042/BSR20231347

Published: 31 May 2024

... and it positively regulates psoriatic keratinocyte proliferation. Our data also showed that GPR15LG could regulate the activity of NF-κB pathway, which is associated with psoriatic inflammation. In the present study, we demonstrated that Gpr15lg (ortholog of GPR15LG ) knockdown attenuated the severity of imiquimod...

View articletitled, GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes

Articles

Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis

Maha S. Lokman, Rami B. Kassab, Fatma A.M. Salem, Gehad E. Elshopakey, Akram Hussein, Ahmed A. Aldarmahi, Abdulrahman Theyab, Khalid J. Alzahrani, Khalid E. Hassan, Khalaf F. Alsharif, Ashraf Albrakati, Jehad Z. Tayyeb, Manal El-khadragy, Mariam A. Alkhateeb, Ali O. Al-Ghamdy, Hussam A. Althagafi, Ahmed E. Abdel Moneim, Rehab E. El-Hennamy

Biosci Rep (2024) 44 (5): BSR20232004.

https://doi.org/10.1042/BSR20232004

Published: 27 May 2024

...; Ahmed E. Abdel Moneim; Rehab E. El-Hennamy Asiatic acid (AA) is a polyphenolic compound with potent antioxidative and anti-inflammatory activities that make it a potential choice to attenuate inflammation and oxidative insults associated with ulcerative colitis (UC). Hence, the present study aimed...

View articletitled, Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis

Includes: Supplementary data

Articles

Antiviral effect of baicalein on Porcine Deltacoronavirus infection by regulating the inflammatory responses through PI3K-Akt-NF-κB signaling pathway in cultured cells

Hejuan Liu, Zhanyong Wei, Chenxi Shi, Lu Xia, Yunfei Zhang, Jing Wang, Meile Wang, Sugai Yin, Xianqing Ren

Biosci Rep (2024) BSR20231930.

https://doi.org/10.1042/BSR20231930

Published: 07 May 2024

... and be freely available under a Creative Commons licence. porcine deltacoronavirus baicalein antiviral activity inflammation PI3K-Akt-NF-κB signaling pathway Science and Technology Department of Henan Province (河南省科学技术厅) 10.13039/501100011447 202102310504 Yin Sugai MOST | National...

View articletitled, Antiviral effect of baicalein on Porcine Deltacoronavirus infection by regulating the inflammatory responses through PI3K-Akt-NF-κB signaling pathway in cultured cells

Articles

Expression of Concern: C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

Biosci Rep (2024) 44 (4): BSR-2019-0888_EOC.

https://doi.org/10.1042/BSR-2019-0888_EOC

Published: 24 April 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atrial fibrillation inflammation NF-κB Toll-like receptor 4 transforming...

View articletitled, Expression of Concern: C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

Articles

Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration

David S. Hansman, Yuefang Ma, Daniel Thomas, Justine R. Smith, Robert J. Casson, Daniel J. Peet

Biosci Rep (2024) 44 (4): BSR20231904.

https://doi.org/10.1042/BSR20231904

Published: 16 April 2024

... cocktail, which led to a substantial 70% increase in lactate production (Supplementary Figure S1). carbohydrate metabolism cytokines glycolysis inflammation retinal degeneration retinal pigment epithelium University of Adelaide Biochemistry trust Fund National Health...

View articletitled, Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration

Includes: Supplementary data

Articles

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome

Rahul Kumar, Neha Chanana, Kavita Sharma, Tsering Palmo, Michael H. Lee, Aastha Mishra, Kevin Nolan, Dara C. Fonseca Balladares, Claudia Mickael, Mohit D. Gupta, Tashi Thinlas, Qadar Pasha, Brian B. Graham

Biosci Rep (2023) 43 (11): BSR20231561.

https://doi.org/10.1042/BSR20231561

Published: 30 November 2023

.... The principal component analysis demonstrated a clear separation of the groups by altitude and treatment. HA exposure resulted in a large number of gene expression changes, particularly in pathways of inflammation or the regulation of cell division, translation, or transcription. DEX prophylaxis resulted...

View articletitled, Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome

Articles

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Barakat M. ALRashdi, Roaya A. Mohamed, Amal H. Mohamed, Feryal A. Samoul, Mazen I. Mohamed, Mohsen M. Moussa, Saad M. Alrashidi, Bassel Dawod, Ola A. Habotta, Ahmed E. Abdel Moneim, Shimaa S. Ramadan

Biosci Rep (2023) 43 (11): BSR20231130.

https://doi.org/10.1042/BSR20231130

Published: 10 November 2023

... demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Tur-SeNPs...

View articletitled, Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Articles

Branched-chain fatty acids affect the expression of fatty acid synthase and C-reactive protein genes in the hepatocyte cell line

Paulina Gozdzik, Aleksandra Czumaj, Tomasz Sledzinski, Adriana Mika

Biosci Rep (2023) 43 (10): BSR20230114.

https://doi.org/10.1042/BSR20230114

Published: 31 October 2023

...-methyltetradecanoic acid, 12-MTA) on selected genes related to fatty acid synthesis and inflammation: FASN , SREBP1 , CRP , and IL-6 in the HepG2 cell line. We observed lowered expression of FASN , SREBP1 , CRP , and IL-6 in cells treated with 14-MPA in comparison with control cells. In contrast, supplementation...

View articletitled, Branched-chain fatty acids affect the expression of fatty acid synthase and C-reactive protein genes in the hepatocyte cell line

Articles

Expression of Concern: SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Biosci Rep (2023) 43 (8): BSR-2018-0541_EOC.

https://doi.org/10.1042/BSR-2018-0541_EOC

Published: 31 August 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . fibroblast-like synoviocytes inflammation NF-κB rheumatoid arthritis...

View articletitled, Expression of Concern: SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Articles

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion

Feng Chen, Yi-hong Chai, Fa Zhang, Yong-qiang Liu, Yan Zhang, Ya-jing Shi, Jian-ming Zhang, Yu-fang Leng

Biosci Rep (2023) 43 (8): BSR20230539.

https://doi.org/10.1042/BSR20230539

Published: 25 August 2023

... with equal amounts of saline at the same time point. After the mice in each group were executed, blood specimens and intestinal tissue specimens (10 cm from the ileocecal area) were gathered for examination. inflammation intestinal ischemia-reperfusion injury network pharmacology Salidroside...

View articletitled, Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion

Includes: Supplementary data

Articles

Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play

Suktara Guria, Anupama Hoory, Snehasis Das, Dipanjan Chattopadhyay, Sutapa Mukherjee

Biosci Rep (2023) 43 (3): BSR20220200.

https://doi.org/10.1042/BSR20220200

Published: 09 March 2023

... AT inflammation is prevalent during obesity. The adipose tissue macrophages (ATM) with astounding heterogeneity and complex regulation play a decisive role in mediating obesity-induced insulin resistance. Adipose-derived macrophages were broadly classified as proinflammatory M1 and anti-inflammatory M2 subtypes...

View articletitled, Adipose tissue macrophages and their role in obesity-associated insulin resistance: an overview of the complex dynamics at play

Articles

Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies

Alyson Deprez, Zakaria Orfi, Lupann Rieger, Nicolas Alexandre Dumont

Biosci Rep (2023) 43 (1): BSR20220284.

https://doi.org/10.1042/BSR20220284

Published: 06 January 2023

... dystrophies that intrinsically compromise MuSC function and/or disturb their microenvironment leading to impaired muscle regeneration that contributes to disease progression. Alternatively, many acquired myopathies caused by comorbidities (e.g., cardiopulmonary or kidney diseases), chronic inflammation...

View articletitled, Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies

Articles

Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Biosci Rep (2022) 42 (12): BSR-2017-1294_RET.

https://doi.org/10.1042/BSR-2017-1294_RET

Published: 22 December 2022

... BY) . diabetic impaired wound healing inflammation NF-κB Vitamin D ...

View articletitled, Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Articles

Insights into mechanisms of graft-versus-host disease through humanised mouse models

Amal Elhage, Chloe Sligar, Peter Cuthbertson, Debbie Watson, Ronald Sluyter

Biosci Rep (2022) 42 (9): BSR20211986.

https://doi.org/10.1042/BSR20211986

Published: 05 September 2022

... haematopoietic stem cell transplantation Antigen presenting cell Graft-versus-host disease Inflammation Lymphocyte Xenogeneic graft-versus-host disease Graft-versus-host disease (GVHD) is an inflammatory disorder that can occur following allogeneic haematopoietic stem cell transplantation (HSCT) [ 1...

View articletitled, Insights into mechanisms of graft-versus-host disease through humanised mouse models

Articles

TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling

Zhongnan Ma, Chuang Wang, Xiufeng Bai, Long Wang, Qianjing Wu, Zehong Cai, Wanxiang Wang, Zhuo Ma, Xinyu Liu, Jiaxuan Feng, Rui Feng

Biosci Rep (2022) 42 (7): BSR20212064.

https://doi.org/10.1042/BSR20212064

Published: 18 July 2022

...-kB subunit) and AKT (AKT serine/threonine kinase 1) are important transcription factors in regulating inflammation. For instance, oxidized LDLs (oxLDLs) or LPS triggers vascular inflammation leading to atherosclerosis through activated NFκB. The study suggests that increased oxLDLs lead to sustained...

View articletitled, TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling

Includes: Supplementary data

Articles

Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells

Victory Ibigo Poloamina, Wondwossen Abate, Gyorgy Fejer, Simon K. Jackson

Biosci Rep (2022) 42 (7): BSR20220251.

https://doi.org/10.1042/BSR20220251

Published: 15 July 2022

...Victory Ibigo Poloamina; Wondwossen Abate; Gyorgy Fejer; Simon K. Jackson Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although...

View articletitled, Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells

Includes: Supplementary data

Articles

Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal inflammation and modulate the gut microbiota in mice

Xiaoya Wang, Xinyu Zhang, Jianqing Su, Xiuling Chu

Biosci Rep (2022) 42 (2): BSR20212670.

https://doi.org/10.1042/BSR20212670

Published: 07 February 2022

...Xiaoya Wang; Xinyu Zhang; Jianqing Su; Xiuling Chu Here, we study the therapeutic effect of Acanthopanax senticosus total flavonoids (ASTFs) using a mouse intestinal inflammation model. The inflammation model used in the present study was developed through lipopolysaccharide (LPS) treatment of mice...

View articletitled, Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal inflammation and modulate the gut microbiota in mice

Includes: Supplementary data

Articles

Correction: Red Algae Natural Products for Prevention of Lipopolysaccharides (LPS)-induced liver and kidney inflammation and Injuries

Biosci Rep (2021) 41 (10): BSR-2020-2022_COR.

https://doi.org/10.1042/BSR-2020-2022_COR

Published: 18 October 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . G. Oblongata red algae Natural products LPS Liver Kidney Inflammation...

View articletitled, Correction: Red Algae Natural Products for Prevention of Lipopolysaccharides (LPS)-induced liver and kidney inflammation and Injuries

Articles

Exosomes derived from LPS-stimulated human thymic mesenchymal stromal cells enhance inflammation via thrombospondin-1

Qianru Li, Jing Li, Lei Sun, Yun Sun, Fei Zhao, Pingping Liu, Xin Peng, Xiaoyan Xuan, Yun Li, Peng Wang, Chen Tan, Ying Du

Biosci Rep (2021) 41 (10): BSR20203573.

https://doi.org/10.1042/BSR20203573

Published: 12 October 2021

... that thrombospondin-1 (TSP-1) is highly expressed in response to inflammation. In this work, we isolated and identified human thymic mesenchymal stromal cells (tMSCs) and detected the expression of TSP-1. We found that tMSCs expressed TSP-1 and Poly (I:C) or LPS treatment promoted the expression of TSP-1. Further, we...

View articletitled, Exosomes derived from LPS-stimulated human thymic mesenchymal stromal cells enhance inflammation via thrombospondin-1

Includes: Supplementary data

Articles

Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19

In Collection

Coronavirus

Aline H. de Nooijer, Inge Grondman, Simon Lambden, Emma J. Kooistra, Nico A.F. Janssen, Matthijs Kox, Peter Pickkers, Leo A.B. Joosten, Frank L. van de Veerdonk, Marc Derive, Sebastien Gibot, Mihai G. Netea, on behalf of RCI-COVID-19 study group

Biosci Rep (2021) 41 (7): BSR20210940.

https://doi.org/10.1042/BSR20210940

Published: 22 July 2021

... BY) . coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acute respiratory distress syndrome (ARDS) inflammation sTREM-1 mortality The current coronavirus disease 2019 (COVID-19) pandemic has, to date, led to almost three million deaths (World Health...

View articletitled, Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19

Includes: Supplementary data

Articles

Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males

Rob G.H. Driessen, Dorien Kiers, Casper G. Schalkwijk, Jean L.J.M. Scheijen, Jelle Gerretsen, Peter Pickkers, Marcel C.G. van de Poll, Iwan C.C. van der Horst, Dennis C.J.J. Bergmans, Matthijs Kox, Bas C.T. van Bussel

Biosci Rep (2021) 41 (7): BSR20210954.

https://doi.org/10.1042/BSR20210954

Published: 02 July 2021

...Rob G.H. Driessen; Dorien Kiers; Casper G. Schalkwijk; Jean L.J.M. Scheijen; Jelle Gerretsen; Peter Pickkers; Marcel C.G. van de Poll; Iwan C.C. van der Horst; Dennis C.J.J. Bergmans; Matthijs Kox; Bas C.T. van Bussel Background: Hypoxia and inflammation are hallmarks of critical illness, related...

View articletitled, Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males

Articles

Correction: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Biosci Rep (2021) 41 (7): BSR-2019-2668_COR.

https://doi.org/10.1042/BSR-2019-2668_COR

Published: 02 July 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adiponectin human periodontal ligament cells inflammation...

View articletitled, Correction: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Articles

Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12 , through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin

Waruni C. Dissanayake, Jin Kyo Oh, Brie Sorrenson, Peter R. Shepherd

Biosci Rep (2021) 41 (7): BSR20211066.

https://doi.org/10.1042/BSR20211066

Published: 29 June 2021

... inflammation macrophages Macrophages are highly sensitive to environmental stimuli. To acquire distinct functional phenotype against host cell infection, macrophages can be polarised into either pro-inflammatory cytokine secreting-classically activated (M1) or anti-inflammatory cytokine secreting...

View articletitled, Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12 , through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin

Articles

The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice

Maria E. Hammarlund, Vladimer Darsalia, Filip Mjörnstedt, Bagmi Pattanaik, Carina Mallard, Eridan Rocha-Ferreira, Cesare Patrone, Maria E. Johansson

Biosci Rep (2021) 41 (6): BSR20210736.

https://doi.org/10.1042/BSR20210736

Published: 11 June 2021

...Maria E. Hammarlund; Vladimer Darsalia; Filip Mjörnstedt; Bagmi Pattanaik; Carina Mallard; Eridan Rocha-Ferreira; Cesare Patrone; Maria E. Johansson Inflammation plays a central role in stroke-induced brain injury. The alpha7 nicotinic acetylcholine receptor (α7nAChR) can modulate immune responses...

View articletitled, The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice

Includes: Supplementary data

Articles

The role of the microbiome in gastrointestinal inflammation

David J. Sanders, Saskia Inniss, Gregory Sebepos-Rogers, Farooq Z. Rahman, Andrew M. Smith

Biosci Rep (2021) 41 (6): BSR20203850.

https://doi.org/10.1042/BSR20203850

Published: 11 June 2021

... to preserve intestinal homoeostasis, promote protective immune responses, and limit excessive inflammation. The importance of the microbiome is further highlighted during dysbiosis where a loss of this finely balanced microbial population can lead to mucosal barrier dysfunction, aberrant immune responses...

View articletitled, The role of the microbiome in gastrointestinal inflammation

Articles

Expression of Concern: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Biosci Rep (2021) 41 (5): BSR-20192668_EOC.

https://doi.org/10.1042/BSR-20192668_EOC

Published: 14 May 2021

... adiponectin human periodontal ligament cells inflammation lipopolysaccharide osteogenic differentiation The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst...

View articletitled, Expression of Concern: Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Articles

Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Biosci Rep (2021) 41 (4): BSR-20192639_RET.

https://doi.org/10.1042/BSR-20192639_RET

Published: 19 April 2021

..., alerting the authors to duplications in Figures 2C, 5A and 5C. This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. acute lung injury apoptosis inflammation PPARγ PTEN/β-catenin pathway sepsis © 2021 The Author(s). 2021...

View articletitled, Retraction: The protective effect of PPARγ in sepsis-induced acute lung injury via inhibiting PTEN/β-catenin pathway

Articles

Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Biosci Rep (2021) 41 (4): BSR-20193419_EOC.

https://doi.org/10.1042/BSR-20193419_EOC

Published: 31 March 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB...

View articletitled, Expression of Concern: miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Articles

Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Xiao-Li Chen, Qing-Ling Xiao, Zhong-Hua Pang, Cheng Tang, Qi-Yong Zhu

Biosci Rep (2021) 41 (3): BSR20204247.

https://doi.org/10.1042/BSR20204247

Published: 24 March 2021

... was quantified based on a five-point system based on the percentage of epithelium occupied by goblet cells: 0, 0% (no goblet cells), 1, <25% of the epithelium, 2, 25–50%, 3, 50–75%, and 4, >75%. The mean scores were calculated from 8 mice [ 35 ]. An-Chuan Granule Asthma Inflammation Network...

View articletitled, Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

Includes: Supplementary data

Articles

Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Huan-huan Wu, Yuan Guo, Yin-fei Pu, Zhi-hui Tang

Biosci Rep (2021) 41 (3): BSR20192668.

https://doi.org/10.1042/BSR20192668

Published: 02 March 2021

...Huan-huan Wu; Yuan Guo; Yin-fei Pu; Zhi-hui Tang Periodontal diseases are infections of the structures that surround and support the teeth; they are characterized by local inflammation and alveolar bone loss. Most treatments focus on only one aspect, inhibiting inflammation, or promoting...

View articletitled, Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs

Articles

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Asmaa Nabil-Adam, Mohamed A. Shreadah

Biosci Rep (2021) 41 (1): BSR20202022.

https://doi.org/10.1042/BSR20202022

Published: 15 January 2021

...Asmaa Nabil-Adam; Mohamed A. Shreadah Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic...

View articletitled, Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Articles

Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation

Shunwan Jiang, Zhi Chen, Wenqiang Lai, Qingchun Mai, Dayu Chen, Shufen Sun, Yong Zhang

Biosci Rep (2020) 40 (12): BSR20201981.

https://doi.org/10.1042/BSR20201981

Published: 21 December 2020

...Shunwan Jiang; Zhi Chen; Wenqiang Lai; Qingchun Mai; Dayu Chen; Shufen Sun; Yong Zhang Traditional Chinese medicine (TCM), such as Huanglian-Jie-Du-Tang, a heat-clearing and detoxifying decoction is beneficial for alleviation of inflammation-related diseases. The objective of the present study...

View articletitled, Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation

Articles

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes

Pengzhen Wang, Qingqi Meng, Wen Wang, Shaoheng Zhang, Xifeng Xiong, Shengnan Qin, Jinli Zhang, Aiguo Li, Zhihe Liu

Biosci Rep (2020) 40 (11): BSR20203107.

https://doi.org/10.1042/BSR20203107

Published: 23 November 2020

...Pengzhen Wang; Qingqi Meng; Wen Wang; Shaoheng Zhang; Xifeng Xiong; Shengnan Qin; Jinli Zhang; Aiguo Li; Zhihe Liu Articular cartilage injury or defect is a common disease and is mainly characterized by cartilage degradation because of chondrocyte inflammation. By now, there are no effective drugs...

View articletitled, Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes

Articles

Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability

Tao Hu, Zhiwen Luo, Kai Li, Shanjin Wang, Desheng Wu

Biosci Rep (2020) 40 (10): BSR20201098.

https://doi.org/10.1042/BSR20201098

Published: 23 October 2020

... against this condition. The present study aims to investigate the protective effect of Zanthoxylum nitidum (ZN) on BMP-2-related hyperpermeability and inflammation on the human umbilical vein endothelial cells (HUVECs). The results revealed that, in a concentration-dependent manner, BMP-2 enhanced...

View articletitled, Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability

Articles

Amelioration of cyclophosphamide-induced myelosuppression during treatment to rats with breast cancer through low-intensity pulsed ultrasound

Wei Wang, Dong Luo, Junlin Chen, Jinyun Chen, Yi Xia, Wenzhi Chen, Yan Wang

Biosci Rep (2020) 40 (9): BSR20201350.

https://doi.org/10.1042/BSR20201350

Published: 24 September 2020

... License 4.0 (CC BY) . Breast cancer chemotherapy hematopoiesis inflammation low-intensity pulsed ultrasound myelosuppression Breast cancer is the most frequently diagnosed cancer in women worldwide and the leading cause of cancer-related deaths among women in less-developed countries...

View articletitled, Amelioration of cyclophosphamide-induced myelosuppression during treatment to rats with breast cancer through low-intensity pulsed ultrasound

Articles

Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia

Hung-Ju Lin, Sung-Liang Yu, Ta-Chen Su, Hsiu-Ching Hsu, Ming-Fong Chen, Yuan-Teh Lee, Kuo-Liong Chien, Tzu-Pin Lu

Biosci Rep (2020) 40 (9): BSR20201885.

https://doi.org/10.1042/BSR20201885

Published: 21 September 2020

...Hung-Ju Lin; Sung-Liang Yu; Ta-Chen Su; Hsiu-Ching Hsu; Ming-Fong Chen; Yuan-Teh Lee; Kuo-Liong Chien; Tzu-Pin Lu Statins inhibit cholesterol biogenesis and modulate atheroma inflammation to reduce cardiovascular risks. Promoted by immune and non-immune cells, serum C-reactive protein (CRP) might...

View articletitled, Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia

Includes: Supplementary data

Articles

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

Amal Ahmed Mohamed, Wafaa Gh. Shousha, Moushira Erfan Zaki, Hala T. El-Bassyouni, Hadeel El-Hanafi, Sara M. Abdo

Biosci Rep (2020) 40 (9): BSR20192910.

https://doi.org/10.1042/BSR20192910

Published: 21 September 2020

... of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Methods: Out of 130 females, 70 were categorized into three obesity groups: Class I, body mass index (BMI) 30–34.9 kg/m 2 ; Class II, BMI 35–39.9 kg/m 2 and Class III BMI ≥ 40 kg/m 2 , besides 60 control...

View articletitled, Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

Articles

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

Shijie Gao, Liang Liu, Shibo Zhu, Dawei Wang, Qiang Wu, Guangzhi Ning, Shiqing Feng

Biosci Rep (2020) 40 (9): BSR20192095.

https://doi.org/10.1042/BSR20192095

Published: 16 September 2020

...-regulate EIF4G2 expression in chondrocytes, while miR-197 knockdown could elevate EIF4G2 expression. Additionally, EIF4G2 overexpression reversed the effects of miR-197 mimics on chondrocytes proliferation, migration, and inflammation. Taken together, our study demonstrated that miR-197 promotes...

View articletitled, MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

Articles

Retraction: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

Biosci Rep (2020) 40 (9): BSR-20190700_RET.

https://doi.org/10.1042/BSR-20190700_RET

Published: 01 September 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Inflammation MicroRNA-142-3p Nuclear factor-kappa B Proliferation Tumor...

View articletitled, Retraction: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

Articles

Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer

Song Yang, Han Wang, Chundi Qin, Hongmei Sun, Yupeng Han

Biosci Rep (2020) 40 (8): BSR20201169.

https://doi.org/10.1042/BSR20201169

Published: 20 August 2020

..., decreased the expression of caspase-3 and BAX at protein level. CXCL8 ERK Inflammation liver cancer malignant progression A commercial human tissue microarray containing 40 liver cancer and 40 normal liver tissue samples (Alenabio, Xi'an, China) was used to estimate the expression of CXCL8...

View articletitled, Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer

Articles

Correction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Biosci Rep (2020) 40 (7): BSR-20193431_COR.

https://doi.org/10.1042/BSR-20193431_COR

Published: 30 July 2020

.... Data are presented as mean±SEM, n = 6, ### P <0.001 vs. the control group, ** P <0.01 and *** P <0.001 vs. the ox-LDL group. The original article “Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway” ( Biosci Rep (2019) 40 (3...

View articletitled, Correction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Articles

miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Yongjun Wang, Huan Li, Yongsheng Shi, Shuying Wang, Yan Xu, Hanyi Li, Donghai Liu

Biosci Rep (2020) 40 (7): BSR20193419.

https://doi.org/10.1042/BSR20193419

Published: 07 July 2020

... to the instruction of dual-luciferase reporter kit (D0010, Solarbio, Beijing, China). apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB signaling pathway Mycoplasma pneumoniae (MP) is a Gram-negative microorganism and the main cause of respiratory tract infection...

View articletitled, miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway

Articles

Correction: Sub-chronic toxicity evaluation of top-three commercial herbal anti-malarial preparations in the Kumasi metropolis, Ghana

Biosci Rep (2020) 40 (7): BSR-20192536_COR.

https://doi.org/10.1042/BSR-20192536_COR

Published: 03 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biochemical haemolysis histology inflammation safety Surveillance...

View articletitled, Correction: Sub-chronic toxicity evaluation of top-three commercial herbal anti-malarial preparations in the Kumasi metropolis, Ghana

Articles

Expression of Concern: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

Biosci Rep (2020) 40 (6): BSR-20190700_EOC.

https://doi.org/10.1042/BSR-20190700_EOC

Published: 25 June 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . MicroRNA-142-3p Inflammation Proliferation Tumor necrosis factor α...

View articletitled, Expression of Concern: Downregulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting Nuclear factor-kappa B signaling

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