... to characterize dKO mice. dKO mice of both sexes, when exposed to an HFD, showed reduced glucose tolerance, hyperinsulinemia, and insulin resistance compared with controls. Moreover, they displayed increased liver weight with worsened hepatic steatosis. Mice displayed significantly increased body weight, which...

..., attention has turned towards HDL composition and vascular protective functions. In individuals with insulin resistance, exercise interventions recover HDL function. However, the effect of exercise on HDL in otherwise healthy individuals is unknown. This cross-sectional study aimed to measure HDL composition...

... in adulthood [ 9 ]. insulin resistance obesity placenta Medical University of Graz DP-iDP Anniversary Fund, Austrian National Bank, Vienna, Austria 17950 Anniversary Fund, Austrian National Bank, Vienna, Austria 17950 Austrian Science Fund (FWF) 501100002428 DOC 31...

... AT inflammation is prevalent during obesity. The adipose tissue macrophages (ATM) with astounding heterogeneity and complex regulation play a decisive role in mediating obesity-induced insulin resistance. Adipose-derived macrophages were broadly classified as proinflammatory M1 and anti-inflammatory M2 subtypes...

... in the development of insulin resistance and DM [ 4–6 ], and is associated with microvascular complications in patients with Type 2 diabetes (T2D) [ 7 ]. The mechanisms underlying the relationship between obesity and DM are not yet fully understood [ 8 ]. Correspondence: Guixia Wang ( [email protected]...

... metabolism hepatocyte steatosis insulin resistance nonalcoholic fatty liver disease proteomics type 2 diabetes mellitus Disorders in glycolipid metabolism are characterized by altered glucose and lipid metabolism, with neuroendocrine disorders, insulin resistance (IR), oxidative stress, altered...

... of high sugar and high-fat diet (HSFD) and streptozotocin (STZ). The T2DM rats were administrated with low (2 g.kg −1 ) and high (5 g.kg −1 ) doses of MFAE for 60 consecutive days. The biochemical indices of glucose metabolism disorders, insulin resistance and oxidative stress were observed. The results...

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cajanonic acid A IL-6 insulin resistance TGF-β Th17/Treg...

... of insulin resistance in the pathogenesis of type 2 diabetes. In the present study, MECR activity was investigated in diet-induced obese (DIO) mice. Mecr mRNA was induced by insulin in cell culture, and was elevated in the liver of DIO mice in the presence hyperinsulinemia. However, MECR protein...

...Mei Han; Lianghui You; Yanting Wu; Nan Gu; Yan Wang; Xiaodan Feng; Lanlan Xiang; Yajun Chen; Yu Zeng; Tianying Zhong Insulin resistance (IR) has been considered as the common pathological basis and developmental driving force for most metabolic diseases. Long noncoding RNAs (lncRNAs) have emerged...

...Yanfeng Gong; Huanbing Liu; Liming Tao Background: The objectives of the present study are to investigate whether cajanonic acid A (CAA) can reduce insulin resistance (IR) in HepG2 cells and to gain a preliminary understanding of the mechanisms underlying this effect. Methods: Following induction...

...Yuanli Wang; Wenwen Gong; Shaofang Lv; Hongmei Qu; Yanling He Methylation of hypoxia-inducible factor-3α (HIF3A) was previously demonstrated to be highly associated with insulin resistance (IR) in patients with gestational diabetes mellitus (GDM). We aimed to study the therapeutic effects...

...Udayan Ray; Sarbashri Bank; Madawa W. Jayawardana; Jahar Bhowmik; Frank Redwig; Pradipta Jana; Suman Bhattacharya; Emili Manna; Subrata Kumar De; Smarajit Maiti; Philip Roberts-Thomson; Venkat Parameswaran; Asru K. Sinha Lack of insulin or insulin resistance (IR) plays a central role in diabetes...

...Lin Yuan; Peng Tang; Hui-Jiao Li; Na Hu; Xiao-Yu Zhong; Min Lin; Yin-Qiang Sun; Min Lu; Xiong Lu Type 2 diabetes (T2DM) is characterized by hyperglycemia resulting from insulin resistance. Jiao-Tai-Wan (JTW), a traditional Chinese medicine consisting of a 10:1 formulation of Rhizoma Coptidis (RC...

...Amanda C. Okolie; Oluwafemi E. Kale; Odutola Osilesi Recent studies have shown that Type 2 diabetes (T2D) in rats can result through a synergy that links obesity to insulin resistance and β-cell dysfunction. The present study achieved T2D via high fructose (20% w/v , p.o.), streptozotocin single...

... of IL-6 and TNF-α. Serum levels of IL-6 and TNF-α and insulin resistance were significantly higher in cases than the controls. IL-6 showed significant positive correlation with HOMA-IR and TNF-α. CC genotype of IL-6 was associated with the increased risk of Met S ( P =0.016, OR for CC vs GC+GG = 2.33...

..., pregnant rats with hypothyroidism had no influence on insulin resistance (IR), lipid accumulation, and mitochondrial dysfunction in skeletal muscle of the fetal rats. Correspondence: Youmin Wang ( [email protected] ) or Datong Deng ( [email protected] ) * These authors are co-first authors...

...Siou Li; Changhao Yin; Weina Zhao; Haifu Zhu; Dan Xu; Qing Xu; Yang Jiao; Xue Wang; Hong Qiao Whether insulin resistance (IR) predicts worse functional outcome in ischemic stroke is still a matter of debate. The aim of the present study is to determine the association between IR and risk of poor...

... acid oversupply to hepatocytes can establish a vicious cycle involving diminished protein folding, endoplasmic reticulum (ER) stress, insulin resistance and further lipogenesis. This commentary discusses the recent findings of Lai et al. published in Bioscience Reports , that implicate protein kinase C...

...Xiaohong Zhang; Jun Li; Shuiping Zheng; Qiuyun Luo; Chunmei Zhou; Chaoyang Wang Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate...

... of VEGF-A/VEGFR2 signalling and a cascade of events leading to improved insulin sensitivity and glucose tolerance. The role of VEGF-B in metabolic homoeostasis will be discussed in the upcoming chapters. fatty acids insulin resistance metabolic syndrome obesity type 2 diabetes VEGF-B...

...Chenjing Yang; Cho Cho Aye; Xiaoxin Li; Angels Diaz Ramos; Antonio Zorzano; Silvia Mora Mitochondrial dysfunction has been associated with insulin resistance, obesity and diabetes. Hyperinsulinaemia and hyperlipidaemia are hallmarks of the insulin-resistant state. We sought to determine...

.... Nevertheless, its involvement in insulin resistance- and TD2 (Type 2 diabetes)-associated dyslipidaemia remains enigmatic. In the present study, we employed the Psammomys obesus gerbil, a well-established model of insulin resistance and TD2, in order to appreciate the contribution of the AMPK/ACC pathway...