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Keywords: Kynurenic acid
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Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (8): BSR20230595.
Published: 07 August 2023
... but could additionally involve increased flux of plasma free Trp and induction of Trp 2,3-dioxygenase (TDO) by cortisol. The major Kyn metabolite targeted by COVID-19 is kynurenic acid (KA), the Kyn metabolite with the greatest affinity for the aryl hydrocarbon receptor (AhR), which is also activated...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (11): BSR20221682.
Published: 11 November 2022
... phosphoribosyltransferase (QPRT) are up-regulated in a few, but down-regulated in many, cancers. This results in accumulation of the aryl hydrocarbon receptor (AhR) ligand kynurenic acid and in depriving the host of NAD + by blocking its synthesis from quinolinic acid. The host loses more NAD + by up-regulation of the NAD...
Articles
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV
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Journal:
Bioscience Reports
Biosci Rep (2011) 31 (5): 323–332.
Published: 21 April 2011
...Qian Han; Howard Robinson; Tao Cai; Danilo A. Tagle; Jianyong Li Mammalian mAspAT (mitochondrial aspartate aminotransferase) is recently reported to have KAT (kynurenine aminotransferase) activity and plays a role in the biosynthesis of KYNA (kynurenic acid) in rat, mouse and human brains...
