... Commons Attribution License 4.0 (CC BY) . 3-dioxygenase 3dioxygenase Aryl hydrocarbon receptor indoleamine 2 kynurenic acid kynurenine pathway tryptophan 2 tumor immune escape Metabolism of the essential amino acid L -tryptophan (Trp) has gained prominence in cancer research...

...Shazia Dawood; Samina Bano; Abdulla A.-B. Badawy The roles of the kynurenine pathway (KP) of tryptophan (Trp) degradation in serotonin deficiency in major depressive disorder (MDD) and the associated inflammatory state are considered in the present study. Using molecular docking in silico , we...

... a proinflammatory state, inhibit expression of haem oxygenase and activate the extrahepatic kynurenine pathway (KP) thereby further contributing to the Hcy elevation. The hypothesis predicts likely changes in CBS activity and plasma Hcy levels in untreated hepatic porphyria patients and in those receiving hemin...

... Indoleamine 2,3-dioxygenase Kynurenine pathway Nicotinamide Poly (ADP-ribose) polymerase Table 1 Pro- and anti-inflammatory cytokines in COVID-19 patients from Wuhan, China according to intensive care needs ICU vs non-ICU-patients Higher proinflammatory Similar proinflammatory Higher...